Eneuro: surprise! Stroke or medicine to cure! This kind of commonly used antidote can actually help stroke recovery!

April 19, 2018 / Biogen / - naloxone, a life-saving drug used to treat opioid poisoning, can actually reduce brain inflammation in male rats after stroke The preclinical study, published in eneuro, laid the foundation for the development of the first drug to promote stroke recovery, the first major cause of adult disability Photo source: anttila et al., eneuro (2018) Naloxone has been used to prevent opioid poisoning and death ten years ago, and has become a common drug to deal with opioid drug crisis in recent years Although the therapeutic potential of naloxone in stroke has been studied, the research in this field is limited to several 1980s studies and uncertain clinical trials Brandon Harvey and Mikko airavaara explored the study with their colleagues, who found that starting naloxone treatment for one week after a stroke in rats could alleviate the immune response of the brain in the first week and improve neurological function in the second week Naloxone, which has weak action with opioid receptor, has similar effect with naloxone used in clinic, so it can overcome the side effect of activating opioid system The researchers administered naloxone nasal spray Narcan through the nasal cavity to rats The same dose was safe in humans In general, these findings will enable naloxone to be studied in different animals and observed for a longer period of time to determine the recovery, and ultimately explore the effect of naloxone on stroke recovery in humans Reference: Brandon Harvey et al Post stroke internal (+ - naloxone delivery reductions microactivation and improvements behavioral recovery from ischemic investment, eneuro, DOI: 10.1523/enviro.0395-17.2018