End-of-2020 inventory: Science Magazine's breakthrough research!

Researchers have found that as offspring develop, offspring of mothers born in sterile environments may be more susceptible to a variety of diseases, including obesity and glucose tolerance, in order to clarify what causes this As a result of the results, the researchers conducted an in-depth study of short chain fatty acids (SCFAs), a metabolite driven by gut microbes that help promote cell growth and development, and can also act as a signaling molecule for communication between gut microbes and other organs in the body.
Science: A New Breakthrough! Scientists can successfully block leukemia before it occurs! doi:10.1126/science.aax5863 Acute myeloid leukemia (AML, Acute myeloid leukemia) is a blood cancer that affects adults and children and requires multiple genetic mutations to occur, many of which can produce mutations as the body ages This process, which causes specific blood cells to multiply faster than other cells to form their own unique cell population, is the first "blow" to be called "clone hematopoirty with uncertain potential" (CHIP, clonal hematopois of indeterminate potential), which is not necessarily harmful.
If the second blow makes these cells malignant, it will basically ensure that the body will certainly develop leukemia in the near future, with the result that immature, dysfunctional blood cells accumulate rapidly.
In a recent study published in the international journal Science, scientists from Boston Children's Hospital and others intervened in the "second strike" process using a special compound that appeared to be safe in preclinical studies, which may have been able to effectively inhibit progression of the disease before AML occurred.
, the researchers were able to screen patients and track patients who had a cloning process before treating a group of patients with a second mutation.
article, the researchers first studied mice that suffered from the "first hit", which carried a mutation in the CHIP-related DNMT3A gene, and when the researchers introduced the "second hit", the NPM A mutation in the 1 gene causes the mice to develop leukemia later on, but if the mice were treated early with a compound called VTP-50469, the blood cells in the mouse's body before the mutation would stop multiplying, and the mice would never develop leukemia without any toxic effect.
photo Source: STEVE GSCHMEISNER SCIENCE SOURCE: New study overturns cell cycle "snapshot" model doi:10.1126/science.aay8241 cells used since 1974 to make a big decision: Should they replicate or remain stationary? Healthy cells can move forward in either way.
of cancer cells remains in the "on" position.
now, in a new study, researchers at the University of Colorado at Boulder in the United States have overturned the traditional idea of how replication switches work, a model that has been accepted since 1974 and incorporated into current textbooks.
the findings were published online in the journal Science.
many biological systems have evolved ways to adapt their reproductive behavior to their surroundings.
example of wild jackdaws, which hatch fewer eggs when ecosystem resources are limited.
, of course, crows must perceive their ecosystems to make this adjustment.
do the same thing, and the subjects on the cell's surface reach out to the ecosystem around the cell like tiny grips to see what they can catch.
when a special subject/grabber grabs the growth factor molecule, it transmits this signal inside the cell, telling the cell to initiate another cell replication cycle.
when these growth factors are lacking, cells enter a sleep-like state called rest.
: A major breakthrough in human brain project research! SCAPE technology is expected to look at and analyze the neural activity of the human brain in 3D: 10.1126/science.aaz5390 In a recent study published in the international journal Science, scientists from institutions such as the National Center for Neurological Disorders and Stroke research in the United States developed an innovative tool that could help researchers observe and analyze the brain's neural activity in 3D.
Because of the limitations of existing tools, scientists are still unable to effectively study network structures in the nervous system and look at large numbers of brain cells at once; in this study, researchers developed an ultra-fast, 3D imaging technique called ACAPE microscope that helps researchers observe larger volumes of tissue and is much less destructive to fine networks in living cells.
researcher Dr Edmund Talley said the study showed how the power of brain planning technology could be used to help study how the human brain interprets information to produce the body's feelings and thoughts.
SCAPE microscopes can help scientists study large tissue samples that need to be observed in real time at once, and because cells and tissues remain intact and observe at high speeds in three-dimensional space, later researchers need to explore many new issues that were previously impossible to study.
Science: A Big Breakthrough! In a new study, researchers from Shanghai University of Science and Technology, Nan kai University, The Chinese Academy of Sciences, the University of Birmingham in the United Kingdom and the University of Queensland in Australia provide new insights into how a key first-line drug kills TB bacteria.
this paves the way for the development of new antibiotic drugs for the emerging strain of Bacillus tuberculosis.
the findings were published online in the journal Science.
tuberculosis (TB) remains a global health challenge, with about 1.5 million deaths each year, with particularly high rates in India, China and Indonesia.
in view of the emergence and spread of new strains, including multidring-resistant and widely drug-resistant strains, there is an urgent need to better understand the mechanisms by which effective drugs can fight the disease.
the drug the researchers are working on is called ethambutol.
drug has been a major force in the fight against tuberculosis since it was discovered in 1961.
, the drug's "mode of action" --- it kills the bacteria