End-of-2020 inventory: Cell magazine's breakthrough research!

in a review article published in the international journal Cell entitled "The Emerging of Landscape of Immune Cellrapies", researchers from Stanford University School of Medicine and others discussed the current use of immunocellular therapy in the treatment of cancers, infectious diseases and autoimmune diseases, as well as progress in overcoming current barriers in cell engineering. the potential for change in
cells as therapeutic agents was first recognized by scientists in the mid-20th century, when researchers found that when trauma, surgery, and some medical conditions occur, infusion of red blood cells significantly improves the treatment and prognosis of patients, followed by plate plateplate infusions and bone marrow transplants that significantly improve survival rates in patients with blood system diseases.
Recently, with advances in immunology, molecular biology, and virology, as well as advances in cell manufacturing and genetic engineering, researchers have shown great interest in the development of immunocellular therapies, of which T-cell therapy is considered to be the most advanced.
The response rate of recombinant T-cell receptors that can identify tumor antigens to T-cells is impressive, and the embedded antigen receptor modified T-cells also show great potential in treating B-cell malignancies that are resistant to all standard preparations, while virus-specific toxic T-lymphocytes (CTLs) can potentially control certain viral infections in immunodeficiency hosts.
Cell: Uncovering the molecular mechanisms by which body cells react to stress! Doi:10.1016/j.cell.2020.03.049 Cells are often exposed to potentially life-threatening stress environments, such as high temperatures or toxins, and fortunately, our body's cells are a stress management "master" with powerful reaction procedures that stop growing and produce stress-protective factors, as well as large structures such as pressure particles.
In a recent study published in the international journal Cell, scientists from the Dresden University of Technology and others revealed how these mysterious structures were assembled and dissolved and how they were transformed into pathological conditions observed in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS).
ALS is a so far incurable disease of the central nervous system, in which motor neurons (the nerve cells responsible for muscle activity) in the patient's body gradually die, and what is the key role of stress particles in it? The researchers say pressure particles can form in the cytoste and are assembled with a large number of large molecular components, such as messenger RNAs or RNA binding proteins, which often break down when pressure subsides, a process driven by the dynamic properties of pressure particles;
Researcher Dr Titus Franzmann explains that ALS patients often suffer from muscle weakness and paralysis, while motor neurons containing pressure particles slowly degrade and induce a lack of motor function, so we need to gain an in-depth understanding of the complex biological properties of pressure particles to help involve and develop therapeutic strategies to neutralisate the damaging effects of ALS, but the complex environment of the body's cells may hinder the pace of scientists' research.
photo source: Cell, 2020, doi:10.1016/j.cell.2020.05.025 Cell: Significant progress! Chinese scientists have discovered 14 powerful human antibodies to SARS-CoV-2 doi:10.1016/j.cell.2020.05.025 In a new study, from Peking University, Capital Medical University, Academy of Military Medicine, Chinese Medicine Researchers at the Academy of Sciences and Beijing Danshu Pharmaceutical Co., Ltd. successfully identified a variety of highly potency-resistant and antibodies to the disease-causing virus ---, which causes the respiratory disease COVID-19, from recovery plasma through high-flung single-cell sequencing---.
antibodies produced by the body's immune system can be effective in preventing viral infections of cells.
results from animal studies show that the meso-antibodies they found offer a potential treatment for COVID-19, as well as short-term prevention.
this marks an important milestone in the fight against the COVID-19 outbreak.
the findings were published online in the journal Cell.
, there has been an urgent need for effective drugs to cure COVID-19.
re-usable small molecule drugs lack specificity, so efficacy is affected.
plasma therapy showed some efficacy, the supply of plasma during recovery was limited.
active ingredient in plasma therapy is targeted neutralization antibodies.
antibody drug, as a biological agent, has been successfully used in the treatment of HIV, Ebola virus, MERS-CoV coronavirus and other viruses.
, however, it can often take months or even years to develop a clinically appropriate antibody.
Cell: Lack of sleep can be short-lived! Scientists have found that sleep deprivation can lead to the accumulation of reactive oxygen in the gut, which in turn can lead to premature death! Doi:10.1016/j.cell.2020.04.049 The initial symptoms of sleep deprivation are familiar to all, including fatigue, difficulty concentrating, irritability, etc., and few people experience the consequences of prolonged sleep deprivation, including loss of direction, paranoia, and even hallucinations.
Sleep as a pervasive behavior, and the fact that severe sleep deprivation can be fatal, support the idea that sleep deprivation is essential for the body's survival, but researchers don't yet know what causes sleep deprivation; in a recent study published in the international journal Cell entitled "Sleep Ross Can Cause Death through Accumulation of Reactive Oxygens in The Gut," researchers at Harvard Medical School found that lack of sleep can lead to death by accumulating oxygen in the body's intestines.
<!--ewebeditor:page title"--">, using research from fruit flies and mice, the researchers found that sleep deprivation/loss leads to the accumulation of reactive oxygen (ROS, reactive oxygen) and oxidative stress effects, especially in the intestines; ROS is not only associated with sleep deprivation, but is also a driver of death. Neutralizing reactive oxygen is effective in preventing oxidative stress, while also allowing fruit flies that have little or no sleep to have a normal lifespan, and the damage caused by genetically modified expressions of antioxidants or antioxidant enzymes that target the intestines may save the damage caused by ROS; Sleepless body survival may be possible.
: Explore the effects of exercise on the human body at the molecular level doi:10.1016/j