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Image: Researchers Jordi Canals and Alfons Navarro from the Department of Surgery, Internal Medicine and Surgery are the first authors of a study conducted in collaboration with Cristina Vila and Josep M Canals of UB's Department of Biomedical Sciences
Source: University of Barcelona
In a study of lung cancer cell lines, researchers from the University of Barcelona and the Auguste Pi Sanye Institute for Biomedical Research (IDIBAPS) have shown that the same molecular signals that control embryonic development can also control the harm of cancer cells
"In this study, we observed that lung cancer cells, when cultured in human embryonic lung mesenchymal conditioned medium, lost their malignant phenotype, their morphology was altered, and their proliferation was suppressed both in vivo and in vitro
Researchers Jordi Canals and Alfons Navarro from the Department of Surgery, Medicine and Surgery are the first authors of the study in collaboration with Cristina Vila and Josep M Canals of the UB Department of Biomedical Sciences
Effects of the embryonic lung microenvironment
This research stems from two key insights
In this context, the researchers proposed the hypothesis that the characteristics and malignant activity of lung cancer cells can acquire benign characteristics upon contact with the normal embryonic lung microenvironment
To this end, the researchers monitored two types of non-small cell lung cancer cells (the most common subtype of lung cancer), named A549 and H1299, to assess what morphological, functional and molecular changes occurred in the embryonic culture medium
The researchers also assessed differences between tumor formation and xenograft cell growth
According to the researchers, these findings suggest that the embryonic environment enables "recombinant phenotypes and cancer cells, where the DNA is not hermetically sealed, fixed and unidirectional but it is highly plastic, which will allow it to accept stimuli"
Embryonic factor for reprogramming cancer cells
Current treatments for lung cancer and solid tumors mainly induce apoptosis or programmed cell death in cancer cells, and there are some problems with this treatment, such as toxicity and acquisition of resistance to treatment
To do this, the researchers propose that embryonic lung factors need to be analyzed to identify new molecules with drug potential
