EMBO Mol Med: Breakthrough! BAM15 protein can cure obesity!

, June 10, 2020 /PRNewswire/ -- A new study has shown for the first time that a protein called BAM15 can act as an energy decoupling device and could be an effective drug for the treatment of obesity and related diseasesmore than 650 million people worldwide are obese and lead to a range of dangerous health conditions, including type 2 diabetes, heart disease and more than a dozen deadly cancersGlobal lying annually to treat obesity and obesity-related diseases is well over $150 billion"Even so, only a few drugs are currently FDA-approved to treat obesity, and very few people who take them can achieve long-term weight loss," said DrJohn Kirwan, executive director of the Pennington Biomedical Research Center in Baton Rouge, Louisiana,Stopping the obesity epidemic requires new and more effective drugsThe study is a very promising step in the discovery processWe hope that in the near future, BAM15 or related compounds will advance the development of clinical drugs and become a viable treatment option for obese patientspicture source: Kathryn Pergola
BAM15 is different from existing weight control drugs, which control weight primarily by reducing food intake or reducing the body's calorie stakeBAM15 works by reducing the efficiency of mitochondria, which are the source of power for cellsThe result is that the mitochondria burn more energyresearchers believe BAM15 could be used to treat a range of health problems, including diabetes, fatty liver and certain cancersin the new study, Pennington biomedical scientists showed for the first time that mice taking BAM15 burned more calories than mice that did not, resisting weight gainOther benefits of BAM15 include:lower blood sugar and insulin levels;improve the sensitivity of skeletal muscle to insulin, the main risk factor for type 2 diabetes; reduce fat build-up as a whole by limiting the accumulation of fat in the liver, kidneys, and blood; and the accumulation of too much fat in the liver, kidneys or blood can damage organ disease and lead to heart disease the study "BAM15 Mediated Mitochondri al Uncoupling Against Obesity and Improves Glycemic Control" is published in the journal EMBO Molecular Medicine (BioValleyBioon.com) References: Study discovers BAM15 as a treatment for the obesity BAM15-mediated mitochondrial un snois against the obesity and improves glymicce control EMBO Molecular Medicine (2020) DOI: 10.15252/emmm.202012088