EMBO J Cancer Review 2021: The molecular, cellular and tissue origins of cancer

The EMBO Journal Cancer Review 2021 Welcome to scan the code to read this series of review papers containing articles published in The EMBO Journal in 2021, covering all aspects of tumor biology, including hypoxia, cancer evolution, and the role of metabolism in the tumor microenvironment , Cellular senescence, RNA translation regulation, cell communication through extracellular vesicles, autophagy, etc.
, please read
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We hope that these articles will help promote fruitful discussions in this area to achieve the common goal of fighting cancer
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(The content will be updated after publication, so please check the series regularly
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) Featured articles Cancer evolution: Darwin and beyond Evolutionary concepts explaining cancer progression, the selective pressures acting on tumours, and their therapeutic implications are discussed in this comprehensive review.
https://doi.
org/10.
15252/embj.
2021108389Scales of tumour evolutionDynamic EMT : a multi-tool for tumor progressionThis review contrasts classical and non-classical roles of epithelial-mesenchymal transition in diverse aspects of cancer cell biology.
https://doi.
org/10.
15252/embj.
2021108647Dynamic EMT as a multi-tool for tumor progressionCell competition in intratumoral and tumormicroenvironment interactionsIn this review, Rajan Gogna and colleagues integrate developmental and cancer perspectives on the role of cell competition mechanisms as drivers of malignancies at tissue level.
https://doi.
org/10.
15252/embj.
2020107271General mechanisms of cell competitionATP and cancer immunosurveillanceThis review summarizes our current view on the dual roles of signaling via adenosine triphosphate and its degradation products in the tumor microenvironment, affecting intracellular metabolism as well as crosstalk between malignant and immune cells.
https://doi.
org/10.
15252/embj.
2021108130 Extracellular ATP homeostasis in the tumor microenvironmentTumor cell heterogeneity and its transcriptional bases in pancreatic cancer: a tale of two cell types and their many variantsAs part of our Cancer reviews series 2021, Natoli and colleagues revisit the roots of pancreatic tumors , and how their heterogeneity depends on lineage-specific regulatory networks.
https://doi.
org/10.
15252/embj.
2020107206 Transcription factors in the control of gene expression in PDACs Introduction European Molecular Biology Organization European Molecular Biology Organization (EMBO) was formally established in July 1964.
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