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Elimination of Interfering Factors in Gel-Based Bacterial Endotoxin Testing Using Biological Methods

 Last Update: 2022-08-30
 Source: Internet
 Author: User

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Because of the G-factor reaction bypass in the agglutination system of Limulus reagent, it can be activated by β-glucan to produce "false positives" of bacterial endotoxin examination, and biological methods are usually used to eliminate the interference

USP, EP and JP have made a note on the use of limulus reagents in the latest revision of the Uniform Bacterial Endotoxin Test: In addition to endotoxins, limulus reagents also react with certain beta-glucans

Different specific Limulus reagents have different characteristics

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