elife: The diversity of immune cells in the lungs of newborn mice

June 4, 2020 /PRNewswire/--- A new study published in the journal eLife suggests that the explosive growth in the number and type of immune cells in the lungs of newborn mice may help them adapt to breathing and protect them from infectionfindings from Stanford University School of Medicine in the United States provide detailed information about the dramatic changes in immune cells in the lungs of mice from pre-birth to the first few weeks of lifeThis insight could help scientists learn more about how problems in early development can lead to breathing problems later in life, such as asthma in later life"The lungs are born with significant physiological changes that change from a liquid-filled, low-oxygen environment to an oxygen-rich environment filled with air," said Racquel Domingo-Gonzalez, author of thearticle at(photo source:However, how these changes affect the immune cell population during this immune process and the rapid growth of the lungs that follow after birth is unclearto learn more, Domingo-Gonzalez and her co-authors used single-cell transcriptomics to track gene expression in individual immune cells in the lungs before birth and during the first three weeks of life in miceThis enabled them to create a map of all immune cells in the lungs of mice early in lifeteam found that before he was about to be born, the small blood vessels that surrounded the lungs were filled with macrophagesAfter birth, a large number of different types of immune cells appear, which help blood vessels grow, develop the lungs and fight infectionthese findings may help explain why infections, overdoses of oxygen or steroid drugs caused by early-life immune system disorders can lead to lifelong lung disease"Immature lung damage can have far-reaching life-long consequences, as the late stages of pregnancy and the first few years of life are critical moments in lung development," explains co-author Fabio Zanini, a postdoctoral researcher"Our work provides the basis for further study of the diversity of immune cells and their role in lung development," addedauthor, Cristina Alvira, an associate professor of pediatrics at Stanford University School of MedicineThis may eventually lead to new treatments to maintain or enhance lung development in infants and young children "(Bio Valley Bioon.com) Source: Immune Cells and in-the-day in mouse at
at the origin of the original origin: Racquel Domingo-Gonzalez et al, Homeostatic and immunomodulofl of the prolocell in the developing mouse at at resolution, life (2020) DOI: 10.7554/eLife.56890