elife: Study reveals causes of different types of thrombosis

2020 May 13 News / BioValley BIOON / --- according to a recent study published in the "eLife", a newly developed tools based on the cause of blood clots to distinguish between different types of blood clotsThis tool can help doctors diagnose what causes the occurrence of blood clots, and help them choose the right treatmentFor example, the tool can help them determine for people just for a heart attack or stroke, aspirin or other anticoagulants whether it is the best choicea (Source: Www.pixabay.com)together when platelet aggregation, clot occursThis can help prevent bleeding after injury break, but also may be due to blood vessel blockage and cause a stroke or heart attackDrYuqiZhou article explains: "Different types of blood clots caused by different molecules, but they look very similar Furthermore, existing tools and almost impossible to distinguish them microscope.." In order to develop a a more effective way to identify different types of blood clots, Zhou and her colleagues from the collected blood samples of healthy individuals there, and then exposing them to various blood coagulation agentsThe team used a high-throughput imaging flow cytometry technology to capture thousands of images of different types of blood clotsNext, they use a machine learning technique called convolutional neural network to train a computer program, to identify subtle differences clot shapes caused by the different moleculesThey use 25,000 images clot test the functionality of this tool and found that it is possible to distinguish between the majority of clot type imageFinally, they tested whether this new tool called Smart platelet aggregation classifiers (iPAC) can diagnose different types of clots human blood samplesThey were collected from four healthy individuals where the blood sample, and then exposing them to different coagulant, the results show that iPAC can distinguish between different types of clots"We proved, iPAC is a powerful tool to study clot formation underlying mechanisms," Zhou saidShe added that, in view of recent reports that COVID-19 can cause blood clots, although there are a lot of knowledge about the virus is unclear, but one day this technology can also be used to better understand the mechanisms of these clot formation(Biovalley Bioon.com) Information Source: Newtoolhelpsdistinguishthecauseofbloodclots Original source: YuqiZhouetal, Intelligentclassificationofplateletaggregatesbyagonisttype, eLife (2020) .DOI: 10.7554 / eLife.52938