ELife: long term skin irritation may increase the risk of tumor growth

January 19, 2020 / BIOON / -- recently, an international magazine published in eLife In the previous report, scientists from Imperial College of technology found that a special antibody that helps the skin resist harmful substances or infections or promotes the growth of tumors during chronic tissue inflammation can promote the development of tumors When the skin is exposed to chronic inflammation, a defensive mechanism of the skin against environmental attacks can promote the continuous progress of tumors Photo source: cc0 public domain IgE antibody is one of the most common but often inadvertently involved in allergic reactions It is most common in healthy skin and can protect the skin against the infection of harmful substances and parasites However, this study found that repeated exposure to skin stimulating chemicals may lead to chronic inflammation or turn beneficial defense mechanism into harmful defense mechanism; further clarify its The process may help scientists develop new treatments to prevent or treat skin cancer According to researcher mark Hayes, chronic inflammation is related to many types of cancer It can further cause cancer by promoting the survival and growth of cells carrying carcinogenic mutations However, the specific process and the role of IgE antibodies are not clear to researchers so far In this study, the researchers analyzed the changes of skin contact with inflammatory substances They observed that the production of IgE in the skin would increase, and a cell called basophil would also be attracted by the skin When the basophil was activated by IgE, it would stimulate the skin cell division and growth IgE can enhance the skin's defense mechanism by promoting cell growth and thickening on the skin surface to respond to harmful stimulation, the researchers said However, this response is short-lived, and if it lasts for a long time, it will cause tumor growth The researchers found that the chronic activation of IgE induced by inflammation can destroy its protective effect and promote the growth of cancerous skin cells into tumor tissue On the other hand, mice lacking IgE may be protected from tumor in inflammatory response To the researchers' surprise, they found that IgE can protect mice from carcinogens that damage DNA, which reveals the mechanism of tumor growth and the key role of IgE in the process, which may depend on different types of environmental exposure; finally, researcher Jessica Previous studies and this paper have revealed a link between IgE and cancer development, but the role of IgE in the skin obviously depends on the characteristics of the antibody and the microenvironment in which the tumor grows, said strid Original sources: Mark David Hayes, Sophie ward, Greg Crawford, et al., Mark David Hayes et al Implantation induced IgE promotions original hyperplasia and tumour growth, eLife (2020) Doi: 10.7554/elife.51862