eLife: Long-term exercise can create a cancer-inhibiting environment in the body

As we all know, physical exercise can prevent various diseases, large and small, even including the treatment of cancer

Recently, a new study published in the journal eLife by an international research team led by Karolinska Institute in Sweden shows that exercise can indeed increase the activity of the immune system and make anti-tumor cells more effective, thereby improving cancer treatment.

In recent years, the application of sports medicine in tumor treatment has been rapidly developed in the field of clinical oncology

Recently, in a study published in "Medical and Science in Exercise and Exercise", researchers from Edith Cowan University and the Dana-Farber Cancer Institute investigated the potential benefits of exercise for patients with prostate cancer, including exercise for cancer.

Previous studies have proposed some mechanisms by which exercise inhibits tumors, but little attention has been paid to the muscle cytokines secreted by skeletal muscles that are absorbed in large quantities during exercise

Researchers have discovered that muscle cytokines have the ability to inhibit tumor growth

In this study, the researchers analyzed resting serum myogenin levels before and after exercise intervention and their effects on the growth of prostate cancer cells

Including supervised resistance training, autonomous aerobic exercise and protein supplementation

The 12-week exercise intervention allows the patient to accumulate 300 minutes of exercise per week, including 5-9 times of resistance training for the main muscle groups of the upper and lower body, each time 1-4 groups, repeated 6-12 times at maximum intensity

Each exercise lasts about 1 hour, 5-10 minutes of aerobic warm-up and relaxation

Researchers found that exercise intervention was accompanied by an increase in the expression of muscle cytokines, especially OSM.

In addition, they also tested the effect of serum on prostate cancer cell lines after 12 weeks of training

The researchers said that although the direct relationship between muscle cytokines and the growth of prostate cancer cell lines cannot be explained, the intervention serum extracted from the patient's resting state significantly reduced the growth of cancer cells

The corresponding author of the study, Professor Robert Newton of Edith Cowan University's Institute of Sports Medicine, pointed out that muscle cytokines may be a secret weapon to delay or prevent cancer growth

Newton added: "Our research shows that long-term exercise can create a cancer-inhibiting environment in the body

Although the researchers only studied prostate cancer patients, they said that releasing muscle cytokines into the blood should be effective for all forms of cancer

The team is currently conducting further research, including trials of a six-month exercise program for patients with advanced prostate cancer
.

Newton concluded: "These people carry a heavy burden of disease and endure various side effects of treatment, but their bodies can still produce anti-cancer'drugs'
.
" This is important because our research shows that even those who suffer Men with advanced cancer, if they insist on physical exercise, they will not be knocked down by the disease so quickly
.
"

Article link:

https://journals.
lww.
com/acsm-msse/Abstract/9000/Myokine_Expression_and_Tumor_suppressive_Effect_of.
95946.
aspx

https://elifesciences.
org/articles/59996