eLife: How did small moles become melanoma from cancer?

Almost everyone is born with moles , moles may become cancerous melanoma, but how does this cancer happen? A recently published study funded by the National Institutes of Health / National Cancer Institute The reason why moles turn into melanoma provides a new explanation
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Almost everyone is born with moles , moles may become cancerous melanoma, but how does this cancer happen? A recently published study funded by the National Institutes of Health / National Cancer Institute The reason why moles turn into melanoma provides a new explanation
.

11 Yue 23 days, Huntsman Cancer Institute (University of Utah, the HCI ) researchers, dermatology and oncology assistant professor at the University of Utah RobertJudson-Torres PhD, of the " eLife results of a study on" magazine published, Explains how common moles and melanomas form, and why moles can become cancerous into melanomas

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11 Yue 23 days, Huntsman Cancer Institute (University of Utah, the HCI ) researchers, dermatology and oncology assistant professor at the University of Utah RobertJudson-Torres PhD, of the " eLife results of a study on" magazine published, Explains how common moles and melanomas form, and why moles can become cancerous into melanomas

Moles and melanoma are both types of skin tumors.

The previous mainstream " oncogene-induced senescence " ( OIS ) model believed that when melanocytes only have BRAFV600E gene mutations, the cells will stop dividing and form moles

Judson-Torres Robert doctoral research team, with the help of Huntsman Cancer Institute and the University of California, San Francisco collaborators while using transcriptome analysis ( Transcriptomicprofiling ) and digital holography cytometry ( Digital Holographic Cytometry ) in patients with donations Research on moles and melanomas

MiRNA rich in melanocytic nevus induces arrest of human primary melanocytes 

MiRNA rich in melanocytic nevus induces arrest of human primary melanocytes 

Studies have shown that melanocytes do not need additional mutations to transform into melanoma.

In fact, they are affected by environmental signals.

Studies have shown that melanocytes do not need additional mutations to transform into melanoma.
In fact, they are affected by environmental signals.

" The origin of melanoma relies on environmental signals, which provides new prospects for the prevention and treatment of melanoma, prevention, " Dr.

AURKB suppression for BRAFV600E stagnation of vital human-induced moles

AURKB suppression for BRAFV600E stagnation of vital human-induced moles

The above findings also laid the foundation for the development of potential melanoma biomarkers, allowing doctors to detect cancer changes in the blood at an early stage of the disease

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The above findings also laid the foundation for the development of potential melanoma biomarkers, allowing doctors to detect cancer changes in the blood at an early stage of the disease

Reference materials:

[1]https:// class="s1">[1]https:// class="p2">[2]Andrew S McNeal, Rachel LBelote, Hanlin Zeng, Marcus Urquijo, Kendra Barker, Rodrigo Torres, MeghanCurtin, A Hunter Shain, Robert HI Andtbacka, Sheri Holmen, David H Lum, TimothyH McCalmont, Matt W VanBrocklin, Douglas Grossman, Maria L Wei, Ursula E Lang,Robert L Judson-Torres.
 BRAFV600E induces reversible mitoticarrest in human melanocytes via microrna-mediated suppression of AURKB.
 eLife,2021; 10 DOI: 10.
7554/eLife.

70385

[2]Andrew S McNeal, Rachel LBelote, Hanlin Zeng, Marcus Urquijo, Kendra Barker, Rodrigo Torres, MeghanCurtin, A Hunter Shain, Robert HI Andtbacka, Sheri Holmen, David H Lum, TimothyH McCalmont, Matt W VanBrocklin, Douglas Grossman, Maria L Wei, Ursula E Lang, Robert L Judson-Torres BRAFV600E induces reversible mitoticarrest in human melanocytes via microrna-mediated suppression of AURKB eLife, 2021; 10 DOI:.
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10.
7554 / eLife.
70385 in this message