ELife: early life exposure to antibiotics may change the risk of type 1 diabetes

July 26, 2018 / biool / - according to a recent study published in eLife by researchers from the New York University School of medicine, taking only one course of antibiotics in early childhood may increase the risk of type 1 diabetes Photo source: early intestinal microbes of cc0 public domain play a key role in shaping the development of host immune system The researchers found that an early life course of antibiotics (1pat) accelerated the development of type 1 diabetes (T1D) in male NOD mice This single course of treatment will have a profound and lasting impact on intestinal microorganisms, leading to changes in cecum, liver and serum metabolites At the same time, after exposure, the chromatin state of ileum and liver and the disturbance of ileum gene expression are sex dependent, which will change the normal mature mode Total signal changes include changes in specific genes that control innate and adaptive immunity Microbiological analysis showed four microbial groups, each of which could accelerate or prevent the induction of T1D, and in a network model, these were associated with ileal gene expression Therefore, this simplified animal model reveals a variety of possible pathways for the study of this disease: disruption of the early intestinal microbiota results in disruption of the intestinal response, thus accelerating and promoting the development of T1D Reference materials: Xue Song Zhang et al, antibiotic induced acceleration of type 1 diabetes alterers matching of internal intelligence, eLife (2018) Doi: 10.7554/elife.37816