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Diabetes is a serious disease that causes blood sugar levels to be too high
"Hypoxia, which reduces oxygen levels in tissues, has also recently been identified as a detrimental factor in diabetes," explains Zheng Xiaowei, senior laboratory manager at Karolinska Institutet in Stockholm, Sweden
To answer this question, Zheng, Narayanan, Xu, and colleagues recruited 13 non-smoking volunteers with type 1 diabetes and 11 healthy volunteers
Since hypoxia in diabetics increases cellular ROS levels, and HIF-1 helps cells respond to hypoxia, the team hypothesized that inhibiting HIF-1 would lead to overproduction of ROS
Finally, the team demonstrated that restoring HIF-1 function in mice reduced the overproduction of ROS in tissue cells and protected the animals' kidneys from cell death and damage
"We have shown that inhibition of HIF-1 plays a central role in ROS overproduction and tissue damage in diabetes and is therefore a potential therapeutic target for these complications,
Journal Reference :
Cheng Xu, Sampath Narayanan, Xiaowei Zheng, Sofie Eliasson Angelstig, Jacob Grünler, Allan Zhao, Alessandro Di Toro, Luciano Bernardi, Massimiliano Mazzone, Peter Carmeliet, Marianna Del Sole, Giancarlo Solaini, Elisabete A Forsberg, Ao Zhang, Kerstin Brismar , Tomas A Schiffer, Neda Rajamand Ekberg, Ileana Ruxandra Botusan, Fredrik Palm, Sergiu-Bogdan Catrina.
