Eight achievements of Peking University Medicine won the 2022 Huaxia Medical Science and Technology Award

Second prize winning projects: establishment of a new system for the diagnosis and treatment of azoospermia, technological innovation and demonstration and application

The first finisher: Jiang Hui of the Third Hospital

After more than ten years of clinical exploration, application and promotion by the team of Professor Jiang Hui of the Andrology Department of the Third Hospital of Beijing Medical University, the project has promoted and applied the new system of diagnosis and treatment of male azoospermia nationwide, benefiting many male infertility patients
。 For the diagnosis and treatment of azoospermia, mature microsurgical techniques such as microvasectomy, microvasectomy epididymis, microscopic testicotomy and spermatotomy have been established from scratch.
Establish and improve relevant diagnostic technologies and apply and promote them in practical work; It took the lead in formulating the clinical diagnosis and treatment operation specifications of reproductive andrology in China and led the formulation of relevant clinical guidelines, thus forming a complete system
of various diagnosis and treatment methods from conservative treatment to surgical treatment and male fertility preservation.
It has trained 376 andrologists for 252 hospitals in 27 provinces and cities in China, and built platforms such as the China Andrology Microsurgery Training Center, training 65 for 60 hospitals Famous academic leader in andrology and backbone
of microsurgery technology.
Main innovative achievements: 1 Establish a sound azoospermia treatment system to reach the international level
.
2.
Establishment and improvement
of azoospermia diagnosis system.
3.
Basic research, patents and popular science education
.
4.
Demonstration, promotion and application of a new system for the diagnosis and treatment
of azoospermia.
(Project Completers: Jiang Hui, Zhao Lianming, Zhang Zhe, Zhou Huiliang, Dai Yutian, Zhang Haitao, Lian Ying, Yang Yuzhuo, Liu Defeng, Mao Jiaming, Tang Wenhao, Lin Haocheng, Hong Kai, Yuan Renpei, Wu Han).

Third prize winning project: R&D and promotion and application of comprehensive intervention technology for the prevention of childhood obesity

First finisher: Wang Haijun, School of Public Health

Childhood obesity endangers physical and mental health and has become a major public health problem
.
In view of the new characteristics of obesity epidemic, the development of scientifically feasible intervention technologies for childhood obesity suitable for different regions of China has become an urgent problem
to be solved.
The project team led by Professor Wang Haijun has been committed to the research of childhood obesity for more than ten years and has achieved the following innovative results: 1.
The first to discover the important influencing factors of childhood obesity in China: the nonlinear relationship between socio-economic development and the growth of childhood obesity, and the interaction between ethnically specific genes and the environment, which provides support
for elucidating the pathogenesis of childhood obesity and developing intervention technologies.
2.
Break through the limitations of single outcome assessment, clarify the harm of childhood obesity to multiple health outcomes for the first time, and provide key information
for the development of teaching materials and technologies for childhood obesity intervention in China.
3.
Systematically carry out research on intervention technologies for childhood obesity in China, and create comprehensive intervention technologies
to prevent childhood obesity from both the environmental and individual levels.
4.
Innovatively integrate mobile health technology and traditional intervention methods, form a new technology that effectively reduces the obesity rate of children, solve the bottleneck problem of multi-center and large-scale population childhood obesity prevention, fill the gap of childhood obesity intervention in areas with different levels of economic development, and the intervention effect is better than similar international research, and has been highly praised
by international peers.
As the first/corresponding author, he has published more than 100 papers in Chinese and English, presided over the formulation of 2 relevant health industry standards, obtained 3 software copyrights and 2 utility model patents, and published monographs 6 parts
.
The intervention technology has been applied to more than 100 schools in 10 provinces across the country, covering more than 100,000 people, with significant social and economic benefits
.
(Project Completers: Wang Haijun, Song Yi, Liu Zheng, Dong Yanhui, Ma Jun, Wu Yangfeng, Niu Wenyi, Song Jieyun, Li Qin, Lin Lizi, Zhou Shuang, Li Wenhao).

Third Prize Winning Project: Research and Application of Key Mechanisms of Clinical Diagnosis and Treatment of Cirrhosis and Related Complications

First finisher: Xu Xiaoyuan of the First Hospital

Cirrhosis and its complications have always been a difficult point and research hotspot
in clinical work.
Guidelines and consensus on ascites and other complications of liver cirrhosis have been formulated abroad, but they are not fully applicable to Chinese patients
.
Professor Xu Xiaoyuan's team applied for many major special projects and Beijing Municipal Science and Technology Commission projects, established a domestic cohort of hepatitis cirrhosis subjects, clarified that splanchnic vasodilation is a key factor in the occurrence of liver cirrhosis-related complications such as ascites, hepatorenal syndrome, cirrhosis gastrointestinal bleeding, sepsis, etc.
, further refined the diagnosis of mild hepatic encephalopathy, explored the optimal treatment plan for patients with decompensated cirrhosis, and provided a theoretical basis
for the standardized treatment of hepatitis B decompensated cirrhosis 。 As the leader, Professor Xu Xiaoyuan's team organized experts in the fields of hepatology and gastroenterology, infection, pharmacy and statistics of the Chinese Medical Association to formulate guidelines such as "Guidelines for the Prevention and Treatment of Portal Hypertension and Esophagogastric Variceal Bleeding in Cirrhosis", "Guidelines for the Diagnosis and Treatment of Ascites and Related Complications in Cirrhosis", "Guidelines for the Diagnosis and Treatment of Hepatic Encephalopathy in Cirrhosis", "Guidelines for the Diagnosis and Treatment of Cirrhosis" and other guidelines
.
Among them, the "Guidelines for the Diagnosis and Treatment of Ascites and Related Complications of Cirrhosis" and "Guidelines for the Diagnosis and Treatment of Hepatic Encephalopathy with Cirrhosis" are the first guidelines
for the diagnosis and treatment of ascites and hepatic encephalopathy in China.
The English version of the "Guidelines for the Diagnosis and Treatment of Ascites and Related Complications of Cirrhosis" was published in Hepatol Int, and Professor Angeli, editor-in-chief of J Hepatol and president of the International Ascitic Club, commented on the ascites guidelines: "Great country, ambitious goals"
。 (Project completed by: Xu Xiaoyuan, Zhao Jingmin, Xie Wen, Yu Yanyan, Wang Yijin, Cao Ying, Xu Jinghang, Liu Shuhong, Wang Yanbin, Lu Haiying, Jiang Lina, Zhao Hong, Wu Chihong, Liu Hongyang, Deng You).

Third prize winning project: establishment and application of precision diagnosis and treatment system for axillary lymph nodes for breast cancer

The first finisher: Wang Shu of the People's Hospital

Axillary lymph nodes are the main metastatic sites of breast cancer, and the judgment and treatment of axillary staging are of great significance
for the judgment of patient prognosis, the formulation of subsequent treatment plans, and the treatment effect and quality of life of patients in the near and long term.
However, there is still a big gap
between the assessment and treatment mode of axillary lymph nodes in China and the international diagnosis and treatment level.
To this end, Professor Wang Shu's team has established a precision diagnosis and treatment system for axillary lymph nodes for breast cancer based on clinical problems for more than ten years, and pioneered the application of fluorescence tracing technology for sentinel lymph node biopsy surgery in China, which has greatly promoted the development
of sentinel lymph node biopsy technology for breast cancer in China.
In the diagnosis of lymph node metastasis, an innovative in vitro ultrasonic detection system was used to establish a non-invasive evaluation model for accurate prediction of lymph node metastasis.
For the first time in the world, high-resolution dynamic OCT technology was used to conduct prospective lymph node metastasis diagnosis research, and a new technology
for lymph node metastasis diagnosis was established.
The project further focuses on the core issues of accurate layered evaluation and scientific and standardized treatment of axillary lymph nodes in breast cancer, so as to ensure the safety of tumor treatment while preserving the function of
the upper limb on the affected side to the greatest extent.
So far, a complete set of precision diagnosis and treatment system for axillary lymph nodes for breast cancer has been formed, and dozens of domestic companies have applied the axillary lymph node diagnosis and treatment system of this project to their clinical practice
.
(Project Completers: Wang Shu, Liu Miao, Yang Houpu, Wang Chaobin, Peng Yuan, Xie Fei, Wang Siyuan, Tong Fuzhong).

Third Prize Winning Project: Innovation and Application of Vulvovaginal Candidosis Diagnostic Methods and Treatment Plans

The first finisher: Shenzhen Hospital Fan Shangrong

Vulvovaginal candidiasis (VVC) is a common disease in women of childbearing age caused by candida infection of the vulvovagina, which seriously affects the physical and mental health
of patients.
Professor Fan Shangrong's team was funded by the basic research project of Shenzhen Science and Technology Innovation Commission "Research on Key Issues of Vulvovaginal Candidiasis" and other projects, which lasted for 17 years and involved 4 registered clinical trials
.
Key outcomes include: (1) Innovative treatment regimens: First reported regimens with nystatin vaginal tethering for recurrent VVC, comparable to the gold-standard oral fluconazole regimen, with comparable long-term cure rates between nystatin vaginal tethering and oral fluconazole
.
The study established a protocol for the use of nystatin vaginal tethering for the treatment of recurrent VVC, and clarified the clinical effect and safety of several antifungal drugs for the treatment of VVC, and the research results were approved by the British Sexual Health and HIV Society (BASHH).
) and 3 guidelines of the German Union of Medical Sciences (AWM) and other institutions and the Cochrane database
.
(2) Innovation of diagnostic methods: The application of nail violet stained vaginal smear for the diagnosis of VVC was first reported, and the results were cited
by Cochrane database.
(3) Pathogenesis study: It was reported that VVC patients had vaginal allergic reactions, which provided a basis
for the application of anti-allergic treatment to patients in China's "Diagnosis and Treatment Standards for Vulvovaginal Candidiasis (Draft)".
(4) Disease health impact study: The impact of
recurrent VVC on the health of patients was reported.
The results were cited in the American College of Obstetricians and Gynecologists (ACOG) clinical guidelines.

(Project Completer: Fan Shangrong, Liu Xiaoping, Zhu Yuxia, Liang Yiheng, Shan Yingying, Zhong Shilin).

Health Management Award Winning Project: Strategic Research on the Development of Scientific Research in the Field of Nursing and Rehabilitation in China

First finisher: Shang Shaomei, School of Nursing

"Strategic Research on the Development of Scientific Research in the Field of Nursing and Rehabilitation in China" is an emergency management project
of National Nature.
Based on the "Healthy China" strategy, the urgent need for people's life and health challenges, and the growing demand for nursing care in the face of the growing elderly population and the huge group of patients with chronic diseases; However, the development of nursing disciplines in China is still in its infancy, the shortage of professional talents is large, the talent structure does not match the development of first-level disciplines, the development of science and technology in the field of nursing is insufficient, and the science and technology system supporting the first-level disciplines of nursing has not yet been established It is urgent to form a development strategy in the field of nursing in China and guide the development of
nursing.
Professor Shang Shaomei's team systematically analyzed the research development status of global nursing, focusing on the nursing field of NINR in the United States, JSPS in Japan and MRC in the United Kingdom Scientific research development planning, project key layout, etc.
; The analysis of global nursing research from 2009 to 2019 obtained a keyword map and a map of intercountry partnerships; The nursing experts in 27 provinces/municipalities/autonomous regions who conducted research were surveyed, and the situation since the first National Natural Science Foundation of China project in the field of nursing was established in 2006.
Analyze the national strategic needs
in the field of nursing in China.
The project has resulted in the "Country Comparative Analysis Report of Nursing Scientific Research", "2009-2019 Global Research Development Report in the Field of Nursing", " Regarding the National Natural Science Foundation of China's Proposal for the Establishment of Independent Code for Nursing in the Department of Medical Sciences, 15 papers were published in domestic and foreign journals; The research results have made important contributions to promoting the in-depth development of nursing discipline, improving the overall framework of scientific research in the field of nursing, and helping to implement the "Healthy China Strategy".

(Project Completer: Shang Shaomei, Chen Hongbo, Hou Luoya, Dong Xu, Wan Qiaoqin, Shi Yuexian, Lu Han, Wang Cui).