Efficacy and function of the chemical RAW material loratadine and its use

The chemical API loratadine is 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cycloheptano[1,2-b]pyridine-11-subunit)-1-piperidinecarboxylate ethyl ester
.

According to the calculation of dried products, the content of C22H23 ClN2O2 shall not be less than 99.
0%.

The chemical API loratadine is a white or off-white crystalline powder; Odorless
.

Easily soluble in methanol, ethanol or acetone, almost insoluble in water; Slightly soluble
in 0.
1mol/L hydrochloric acid solution.

Drug Name: Loratadine Alias: 4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cycloheptadium [1,2-B]pyridine-11-subunit)-1-Piperidinecarboxylate Ethyl Ester Drug Type: Essential Drug Chemical Formula: C22H23ClN2O2 Molecular Weight: 382.
883 Appearance: White or Off-White Crystalline Powder CAS Registration Number: 79794-75-5 Density: 1.
261 g/ cm³ Melting point: 134 to 136 °C Boiling point: 531.
3 °C Flash point: 275.
1 °C Water solubility: Almost insoluble loratadine API meets the Chinese Pharmacopoeia 20th edition of the second standard loratadine second generation antihistamine, commonly used to treat allergic symptoms
.

It is used for allergic rhinitis, acute or chronic urticaria, allergic conjunctivitis, hay fever and other allergic skin diseases
.

Formulations of the chemical API loratadine include loratadine tablets, loratadine capsules and loratadine granules
.

Loratadine tablets contain 10 mg
of loratadine per tablet.

Excipients are: sodium lauryl sulfate, starch, microcrystalline cellulose, povidone K30, sodium carboxymethyl starch, talc, magnesium stearate
.

Dosage of loratadine: oral
.

Adults and children over 12 years of age: 1 tablet (10 mg)
once a day.

Children 2 to 12 years: body weight>30 kg: 1 tablet (10 mg)
once a day.

Body weight ≤ 30 kg: 1/2 tablet (5 mg)
once a day.

Loratadine has no central sedative effect, only need to be taken once a day, the efficacy can be maintained for 1 day, the patient compliance is better, and the effect on chronic urticaria is better
.

Its efficacy is superior to that of chlorpheniramine, clumastin, terfenadine and asimidazole
.

But the price is more expensive
.

Loratadine is a selective peripheral H1 receptor antagonist without cholinergic and adrenaline antagonism
.

Ophthalmology is mostly used for skin and mucosal tai reactions, such as contact dermatitis of the eyelids and allergic conjunctivitis
.

Loratadine API Chinese medicine quasi word H20030588 Tianfang Pharmaceutical