Effective for a variety of new crown variants!

The menacing new coronavirus Delta variant, in addition to affecting the effectiveness of the vaccine, also brings challenges to the prevention and treatment effects of neutralizing antibodies

However, there are some special Nanobodies that seem to be immune to virus mutations and broadly neutralize mutant strains including Delta variants

In the past year, Professor Shi Yi’s research team and collaborators have quickly identified more than 8,000 nanobodies by immunizing llamas and combining advanced proteomics platform technology, which can bind to the new coronavirus receptors.

The results of these previous studies indicate that Nanobodies will be a promising treatment option

▲The effect of different mutations of spike protein on the affinity of several nanobodies

These results prompted the researchers to further study the structural basis of Nanobodies' broad neutralization ability

The second type of nanobody (including Nb34/Nb95/Nb105) binds to the conserved regions of coronaviruses (such as SARS virus and new coronavirus) and can efficiently neutralize multiple mutant strains

▲The three types of nanobodies efficiently neutralize the new coronavirus with different mechanisms and reduce the possibility of the virus infecting cells (picture source: reference [1])

The researchers concluded: "Based on the neutralizing Nanobodies developed in the early stage, this study provides a framework for systematically mapping the neutralizing antibody epitopes through structure-function research methods, and understands the highly effective and unique inhibitory effects of Nanobodies on viruses and their The mechanism of mutation

Reference materials:

[1] Sun, D.

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