Effect of different concentrations of propofol as the only anaesthetic on pupil diameter: randomized trials.

BACKGROUND: Pupil measurement monitoring under general anaesthetic is based on the assumption that changes in pupil diameter reflect whether the analgesics provided meet the intensity of pain stimulated by injury surgery.
accurate interpretation of pupil measurement data, it is necessary to clearly determine what is the expected baseline for the diameter of the unstimused pupil in each particular hypnotic state.
opioids reduce pupil diameter in dose-dependent ways.
contrast, the effect of hypnotic drugs on pupil diameter is not yet known.
our goal is to explore the potential relationship between the predictive effect point concentration (CET) of propofol and the diameter of the pupil in the range of 1-3 ?g/mL.
method: Patients received propofol-targeted infusions at random, with CETs expected to be 1, 2 or 3 ?g/mL (P1, P2 and P3 groups, respectively).
measured pupil diameter after 10 minutes of steady-state infusion of propofol in a randomly grouped CET.
no stimulation during the study.
continuously recorded heart rate and electroencephalo-double frequency index (BIS).
: A total of 40 patients were included: 13 in P1, 14 in P2 and 13 in P3.
P1 group has an average pupil diameter of 5.7 mm (1 Mm), the P2 group has an average pupil diameter of 4.8 mm (1.3 mm) and the P3 group has an average pupil diameter of 3.3 mm (0.8 mm).
has a dose-dependent effect on pupil diameter (linear regression R2 x 0.45, P.lt;0.001).
diameter of the pupil is positively related to the BIS value (Spearman r?0.75?95%CI 0.5 4, ?0.87?, P?lt;0.0 0 0 1).
conclusion: In the predicted CET range of 1 to 3 ?g/mL, propofol has a dose-dependent effect on pupil diameter.
in this concentration range, BIS is positively related to the diameter of the pupil.
effects of propofol on the cortation of the pupil diameter are related to its effects on the cerebral cortation.
evaluation of pupil diameter as an injury-anti-injury balance indicator should be conducted in patients with standard deep hypnosis.
: Sabourdin N, Meniolle F, Chemam S, et al. Effect of The GreatEr United States of Propofol Used as a Sole Anesthetic on Pupilary Diameter: A Randomized Trial. (J) Anesth Analg 2020, 131:510-517.Effect of The GreatEr Of Theool Used as a Sole Anesthetic on Pupilally Diameter: A RandomIzed Trial AbstractBACK GROUND: Pupillometry monitoring under general anesthesia is based on the assumption of the pupilsary diameter changes reflect the adequacy of the provided analgesia to the intensity of the nociceptive activityus. The accurate image of the user of the pupilometric data requires the establishing clearly what the expected baseline unstimulated pupilary diameter at each some sort of level of hypnosis is. Opioidsary diameter in a dose-dependent fashion. In contrast, the effects of the hypnotic drugs on the pupilary diameter are not well known. Our aim was to describe the potential relationship between propofol predicted effect-site concentrations (Cets) from 1 to 3 sg/mL and pupilary diameter. METHODS: Patients are randomized to receive propofol by target-controlled infusion at a predicted Cet of 1, 2, or 3 ?g/mL (groups P1, P2, and P3, respectively). Pupilary diameter measurements are performed after 10 minutes of steady-state propofol infusion at the randomized Cet. No stimulation was performed at the study. Heart rate and bispectral index (BIS) are continuously recorded. RESULTS: Forty patients are included: (13, 14, and 13 in groups P1, P2, and P3, ally). Mean pupilary diameter was 5.7 mm (1 mm) in group P1, 4.8 mm (1.3 mm) in group P2, and 3.3 mm (0.8 mm) in group P3. Propofol hadd a dose-dependent effect on pupilary diameter (linear regression R2 s 0.45, P .lt; .001). Pupilsary diameters are actively correlated with BIS (Spearman r . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . CONCLUSIONS: From 1 to 3 sg/mL of predicted Cet, propofol has a dose-dependent effect on pupilary diameter. Within this this is the most range, there is a positive correlation between BIS and pupilary diameter. The subcortical effect of propofol on pupilary diameter is correlated to its effect on the cortex. Studies Assessing pupilsary diameter as a marker of the nociception -antinociception balance balance be be performed in patients with a standard depth of the hypnosis. Translation: Ren Wenxin Editor: Feng Yuxuan Review: Cao Ying Source: Poppy !-- Content Display Ends - !-- Determine whether the login ends.