Effect of Atractylodes macrocephala extract on gastrointestinal motility and immune function in experimental spleen deficiency rats

Recently, researchers from the Department of traditional Chinese medicine chemistry, School of medicine, Hubei University of traditional Chinese Medicine published papers to explore the effect of Atractylodes macrocephala extract on gastrointestinal motility and immune function in experimental spleen deficiency rats, and to clarify the mechanism of Atractylodes macrocephala extract regulating gastrointestinal motility and immune function It was pointed out that Atractylodes macrocephala extract could improve gastrointestinal motility and immune function of experimental spleen deficiency rats, and it had a better regulatory and therapeutic effect on gastrointestinal dysfunction and low state of systemic and local immune function caused by spleen deficiency This article was published in the Journal of Jilin University (Medical Edition), the first issue in 2015 60 male SD rats were randomly divided into normal group, model group, low, medium and high dose Atractylodes extract group and domperidone group, 10 rats in each group In addition to the normal group, rats in other groups were fed with Xiaochengqi Decoction and starvation disorder to establish the model of spleen deficiency After the model was established, rats in the low, medium and high dose groups of Atractylodes macrocephala extract were given 0.5, 1.0 and 2.0g · ml-1 Atractylodes macrocephala extract decoction, rats in the domperidone group were given domperidone suspension solution, rats in the normal group and the model group were given normal saline The gastric residual rate and intestinal propulsive ratio of rats were measured by carbon powder gavage method, IgA level in intestinal perfusion fluid of rats was measured by intestinal perfusion method, IgG level in serum and MTL, SP and SS Level in plasma were measured by abdominal aorta blood sampling method, and the expression water of Toll like receptor 4 (TLR4) in duodenum, jejunum and ileum was measured by immunohistochemistry method Ping Compared with the model group, IgA and IgG levels in the intestinal perfusion fluid of rats in the low, middle and high dose Atractylodes extract group and domperidone group were increased, the gastric residual rate was decreased, the intestinal propulsive ratio was increased, while the levels of MTL, SP and SS in the plasma of rats were increased (P < 0.05, P < 0.01); compared with the low dose Atractylodes extract group, I in the intestinal perfusion fluid of rats in the middle and high dose Atractylodes extract group was increased The levels of IgA and IgG in serum, gastric residual rate, intestinal propulsive ratio, MTL, SP and SS in plasma and TLR4 in duodenum, jejunum and ileum were increased (P < 0.05 or P < 0.01).