Eclipta extract or anti-tumor

Yu Qiang research group of Shanghai Institute of medicine, Chinese Academy of Sciences, screened a compound library containing more than 3000 natural products and found that the natural product of Eclipta chinensis extract could significantly enhance IFN - γ signal and enhance its anti-tumor activity The research was published in the American Journal of biochemistry It is reported that interferon - γ is a kind of cytokine with multiple biological functions, which not only plays an important role in controlling human microbial infection, but also has good antitumor activity Yu Qiang et al Found that wedelitrilactone did not affect the binding of IFN - γ to its receptor, but enhanced IFN - γ signal by prolonging the tyrosine phosphorylation of STAT1 (signal transducer and activator of transcription) Further study showed that wedelitrilactone could inhibit the activity of tcptp and prolong the activation signal of STAT1 Cell experiments and in vitro enzyme activity showed that wedelitrilactone was a specific inhibitor of tcptp In particular, wedelitrilactone inhibited the phosphatase by its C-terminal regulatory domain Tyrosine phosphatase (PTP) has become a potential drug target due to its close relationship with many diseases However, the members of PTP family are highly conserved in the catalytic domain, which makes the development of PTP specific inhibitors very difficult This study not only provides a candidate antitumor compound, but also plays an important role in the research and development of PTP inhibitors.