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eClinicalMed: Efficacy of the novel Bruton tyrosine kinase inhibitor Orelabrutinib in the treatment of relapsed/refractory Waldenström macroglobulinemia

 Last Update: 2022-10-12
 Source: Internet
 Author: User

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Orelabrutinib is a novel small molecule selective irreversible Bruton tyrosine kinase inhibitor

This is a prospective, multicenter clinical trial that enrolled patients with R/R WM who

Between August 2019 and December 2020, a total of 66 patients with

For patients with MYD88L265P/CXCR4NEG, MYD88L265P/CXCR4S338X, or MYD88NEG/CXCR4NEG mutations, MRR was 84.

Most of the adverse reactions were grade 1-2 (91.

In summary, Orelabrutinib has demonstrated good efficacy and controlled safety

Original Source:

Xin-xin Cao, et al.

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