EBioMedicine: Disnews! University of Southern California study: Omega-3 fatty acids in fish don't prevent Alzheimer's disease!

Introduction: Earlier studies have shown that fish content and these two omega fatty acids are beneficial to brain function in older adults and may reduce the risk of Alzheimer's disease in older peopleA new study recently contradicted thisA small trial at the University of Southern California found that omega fatty acids in fish have less effect on the brain and do not prevent Alzheimer's diseaseFor years, a scientific conundrum has plagued researchers working to fight Alzheimer's disease, which is incurableAlzheimer's disease is a neurodegenerative brain disease in the brain that destroys brain cells that cause abnormal memory, cognition, thinking and behavioral abilities to seriously affect people's work and life until the body loses functionIt is the most common type of dementiaPrevious epidemiological studies and meta-studies of famous participants showed that omega fatty acids have the potential to prevent Alzheimer's disease, "good fats" are found in fishSo far, however, most studies that have assessed human cognitive decline have not shown any benefitNow a small clinical trial at the University of Southern California has provided important clues to this phenomenonThis is the first time that researchers who have revealed whether omega siscant disease can prevent Alzheimer's disease have compared omegas in the blood to levels in the central nervous systemThe results suggest that more doses of omega fatty acid supplements may be required to change this situation because of a sharp rise in omega fatty acid levels in the blood and a particularly slow increase in omega fatty acid levels in the brainFor participants who carried a specific mutation that increased their risk of developing Alzheimer's disease, the level of a key fatty acid raised by taking supplements was much lower than in those who did not"The experiment was based on the assumption that the omega will enter the brain," said DrHussain Yassin, an associate professor of medicine and neurology at the University of Southern California's Keck School of Medicine and senior author of the studyOur research is specifically designed to solve this problemThe paper was published in the journal BiomedicalThe researchers recruited participants with risk factors for Alzheimer's disease but no cognitive impairment All participants had a family history of the disease, a sedentary lifestyle and a low-fat fish diet One person carries a gene called a gene variant that is associated with inflammation in the brain that increases the risk of Alzheimer's disease by four or more; Participants in the demographics and baseline clinical characteristics of the treatment group were randomly assigned to the treatment group and the control group Members of the treatment group were required to take more than grams of omega-22 hexaxaric acid () supplements daily for several months The control group members were given a placebo daily during the same period Both groups of participants were also asked to take daily multivitamins that helped the body process omega-fatty acids Dr Yassin and his colleagues collected plasma and cerebrospinal fluid samples from participants at the beginning of the study and at the end of the study to measure whether omega fatty acids reach edited in the brain The scientists observed that the levels of two omega-fatty acids, a very effective anti-inflammatory substance, can be produced by a small amount of an effective anti-inflammatory substance Is high doses of omega fatty acids effective? The researchers found that participants who took omega supplements after six months had higher levels of blood than those who took a placebo In contrast, the content of cerebrospinal fluid in the treatment group was only higher than in the control group The results suggest that measuring the amount of omega in the blood does not indicate how much reaches the brain In the treatment group, people who were not at risk of mutation had three times more levels in cerebrospinal fluid (anti-inflammatory omega fatty acids) than those carrying the gene It is worth noting that the dose of grams in this study far exceeds that of the dose stake that tested in large clinical trials to prevent Alzheimer's disease, which is usually taken daily or less It may not be considered pointless to use a low-dose brain to increase the amount of omega The sacrifice of the study participants led to the study of Alzheimer's disease, which researchers spent two years recruiting participants The obstacle to the study comes from the only way to extract cerebrospinal fluid: lumbar punctures are also known as spinal punctures Finding someone willing to undergo the procedure has proved challenging, requiring a hollow needle to pierce the waist twice Dr Yassin spoke highly of the study participants He believes that the participants in the study contributed to the development of science Over a two-year period, the study will study participants to determine whether high doses of omega fatty acids can slow cognitive decline in lipoprotein gene carriers "These preliminary studies are a very important step towards larger, more complex studies," said Dr Yassin, who has changed cognitive scoring Progress from small studies to large-scale studies is a good model for developing brain-specific therapies and prevention The bottom line is that before you start a very expensive clinical trial, you need to prove that your drug is entering the brain and changing the biomarkers of the disease in the right direction "