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Alzheimer's disease (AD) is a neurodegenerative disease with progressive memory and cognitive decline
.
At present, the most commonly used drugs for the clinical treatment of AD are cholinesterase inhibitors donepezil, rivastigmine, galantamine, arizine, etc.
Alzheimer's disease Alzheimer's disease Neurodegenerative disease Neurodegenerative disease Cholinesterase inhibitor Cholinesterase inhibitor Looking for new drugs and treatments Looking for new drugs and treatments
Astragalus Sijunzi Decoction is a traditional Chinese medicine formula commonly used to invigorate qi, nourish yang and dispel dampness , including: astragalus, ginseng, atractylodes, poria, licorice
.
Astragalus, as the main ingredient in the prescription, plays a very effective role in the treatment of many diseases
Sijunzitang tragacanth Astragalus Sijunzitang Jian gas, Yang, dampness of traditional Chinese medicine prescription health gas, Yang, dampness of traditional Chinese medicine prescription Astragalus Sijunzitang AD have a certain effect of Astragalus Sijunzitang AD has some effect
A recent study published in Evid Based Complement Alternat Med, searched for the active ingredients and targets of Huangqi Sijunzi Decoction in the Traditional Chinese Medicine System Pharmacology Database and Analysis Platform (TCMSP), and used UniProt and GeneCard databases to search for the gene name corresponding to the target
.
Cytoscape was used to construct a Chinese herbal medicine-compound-target network and a protein-protein interaction (PPI) network
The compound-target network mainly contains 132 compounds and 255 corresponding targets
.
The main ingredients are quercetin, kaempferol, thorn formononetin and other key targets, including AChE, PTGS2, PPARG, IL- 1B, GSK3B and so on
Thorn formononetin thorn formononetin neuroprotective effects neuroprotective effects
The study clarified the multi-component and multi-target mechanism of Huangqi Sijunzi Decoction in the treatment of AD through network pharmacology methods, molecular docking technology and in vitro experiments, and provided a theoretical basis for the development of Huangqi Sijunzi Decoction as an innovative alternative therapy for AD
The multi-component and multi-target mechanism of Huangqi Sijunzi Decoction in the treatment of AD
Literature source:
Literature source:Zhang W, Lv M, Shi Y, Mu Y, Yao Z, Yang Z.
Zhang W, Lv M, Shi Y, Mu Y, Yao Z, Yang Z.
Network Pharmacology-Based Study of the Underlying Mechanisms of Huangqi Sijunzi Decoction for Alzheimer's Disease.
Evid Based Complement Alternat Med.
2021 Oct 5;2021:6480381.
doi : 10.
1155/2021/6480381.
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