East China University of science and technology designed a new probe for early detection of lung cancer

On November 3, the reporter learned from East China University of science and technology that Wu Junchen's research team of the school of chemistry made important progress in the field of peptide molecular probes They designed a new magnetic light probe based on depolymerization, which can be used to detect early lung cancer The results were published in the journal scientific report According to the prediction of who, by 2025, the number of new lung cancer cases in China will exceed 1 million every year At present, one person dies of lung cancer every 30 seconds Why is the cure rate of lung cancer so low? This is because lung cancer patients are often diagnosed in the middle and late stage Is there a way for lung cancer to show up in the early stage In order to solve this problem, the researchers designed a new type of magnetic optical probe based on depolymerization set for lung cancer detection When the probe is combined with NK1R, the depolymerization of the probe changes from two-dimensional structure to one-dimensional structure, which can significantly enhance the fluorescence and magnetic signals of the molecular probe Therefore, this "one off one on" response can detect the overexpression of NK1R in the serum of lung cancer patients, so as to effectively distinguish tumor patients from the normal population At the same time, the platform provides a new channel for the design of receptor molecular probes, which can be used in other related research fields It is understood that Wu Junchen's team will further expand the application of molecular probes in early diagnosis of tumors, especially by using the high specificity of polypeptide molecular probes, developing molecular probe kits with independent intellectual property rights, and establishing relevant research platforms.