DTI's joint histogram reveals GBM-soaked heterogeneity

Ref: Li C,et alCurry2018 Sep 17doi: 10.1093/neuros/nyy388theglioblastoma (GBM) is a heterogeneous lesions characterized by invasive growth, which is not possible for surgical full removalThe rapid development of tumor after surgery, the emergence of re-incidence near the fieldDispersion ccant imaging (DTI) can be used to determine the range and direction of water molecular motion, and has a certain sensitivity in showing the immersion of tumorsGlioblastoma first attacks and destroys white matter fibrosis, causing water molecules to spread in tumor and tumor-peripheral brain tissue, and DTI breaks down the tensor into anisotropic components (DTI-p) and anisotropy components (DTI-q), showing the dispersal direction of water molecules, which has been clinically proven to predict tumor progression and patient prognosisChao Li of cambridge university's Centre for Brain Tumor Imaging, uk, used DTI's joint histogram analysis to discuss the correlation between GBM's immersion pattern and clinical prognosis, published online in September 2018the study included 115 patients with primary glioblastoma, all of whom underwent MRI imaging and surgical treatment prior to surgeryIn tumor enhancement and non-enhancement areas, build a Joint Histogram of DTI (Figure 1)It was found that the characteristics of the combined histogram were significantly related to patient survivalThe proportion of DTI-p reduction and DTI-q increase in tumor non-enhanced regions was associated with tumor progression (r-0.35, P-0.010);Figure 1DTI joint histogram analysis schematic the authors point out that the test method helps to understand the different characteristics of tumor immersion growth and helps to determine clinical prognosis The reduction of DTI-p and the increase of DTI-q in the non-enhanced region can be considered to be directly related to tumor immersion growth and tumor progression, providing a new basis for guiding surgical excision and radiotherapy (
Wang Chengbin compiled, Fudan University affiliated Huashan Hospital Huashan Hospital, Associate Professor Huayu , editor-in-chief of "Outside The Outside Information", Fudan University affiliated Huashan Hospital Professor Chen Guancheng Final)