Almost two years ago, a study published in a sub-Journal of "Science" was misunderstood by the public to prove that "drinking green tea cures diabetes" and attracted attention.
August 18, "the American Academy of the Academy of Sciences" published its "companion", please T cells can kill tumor cells, "drinking wine", to make them more secure, controlled manner to treat tumors
Academy of Sciences "'Drinking red wine' is a popular term.
The much-anticipated tumor immunotherapy has pain points and can be cured!
The much-anticipated tumor immunotherapy has pain points and can be cured! In 2017, the US FDA successively approved two CAR-T therapies for tumor treatment, but they were not popular due to prominent pain points
One of the pain points of CAR-T therapy is the cytokine storm that is difficult to control
In order to avoid the cytokine storm, the research team used synthetic biology methods to design molecular switches at the DNA level to achieve controllable CAR-T therapy
"We found resveratrol's'response protein' in a kind of bacteria
It is precisely because of the existence of this mechanism related to red wine ingredients (containing resveratrol) that "red wine" can regulate CAR-T cells to kill tumors
Find the key control link, the next step is design and assembly
Genetically modified Brand new CAR, not only with navigation but also with switch
Brand new CAR, not only with navigation but also with switch People often describe CAR in CAR-T therapy as navigation, which means finding tumor cells with T cells
Such a CAR-T is like putting a "precision guided missile" into the body of a tumor patient, but whether the missile explodes or not, it can be remotely controlled by resveratrol outside the body
In the mouse model of human leukemia, the effect of CAR-T with navigation and switch has been verified.
In the ON system, the effect of resveratrol is completely opposite.
When asked why the two systems were designed, Ye Haifeng said that this is for actual clinical needs
"In real life, some patients need to come up to kill tumor cells on a large scale, and some patients need T cells to not recognize or attack the tumor when they first hit the body, but kill them when needed
When can the active ingredients of red wine participate in the treatment of tumors? Ye Haifeng said that the current control system is still some distance away from direct clinical use, and the sensitivity and responsiveness of the switch system need to be further improved in the future
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This is because resveratrol has a strong antioxidant capacity and is easily metabolized in the body
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Further solutions are available and are still being tested
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"In foreign countries, resveratrol is a very common oral health care product.
The reason why resveratrol was chosen as the control molecule is also because its medicinal value has been partially confirmed, and it will be easier to obtain on the road to the clinic.
Pass
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" Ye Haifeng said
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According to reports, the resveratrol-regulated gene expression system constructed by the institute can precisely regulate the therapeutic protein encoded by any gene and be used for other precise and controllable drug delivery.
It is expected to become a safe, precise and controllable new in precision treatment.
Tools
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(Note: Resveratrol used for oral or injection in the study is a chemical preparation and is not given through red wine)
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