Dosage of pharmaceutical grade microcrystalline cellulose 101 in tablets

Pharmaceutical grade microcrystalline cellulose 101 in the use of tablets Pharmaceutical industry microcrystalline cellulose is commonly used as an adsorbent, suspension, diluent, disintegrant
.

Microcrystalline cellulose is widely used in pharmaceutical preparations, mainly as diluents and binders in oral tablets and capsules, not only for wet granulation but also for dry direct tablet pressing
.

There is also a certain lubrication and disintegration effect, which is very useful
in tablet preparation.

Due to the hydrogen bond between microcrystalline cellulose molecules, the hydrogen bond is associated when pressurized, so it has a high degree of compressibility and is often used as an adhesive; After the pressed tablet encounters the liquid, the moisture quickly enters the inside of the tablet containing microcrystalline cellulose, and the hydrogen bond is immediately broken, so it can be used as a disintegrant
.

Therefore, it is an excipient widely used in tablet production, which can improve the hardness of tablets
.

For example, in the preparation of rifampicin tablets, microcrystalline cellulose and starch (mass ratio is 6.
25:1) and various raw materials can be mixed evenly and then directly tableted, and the product disintegrates into a fog within 1 minute
.

Moreover, the content remains unchanged during the validity period and can improve the stability
of the drug very well.

For another example, due to the addition of microcrystalline cellulose, the dissolution of prednisone acetate and berberine acetate (berberine hydrochloride) tablets is increased to more than
80%.

The use of microcrystalline cellulose as an excipient tablet does not need to go through the traditional granulation process, for example, in the preparation of cough Biqing tablets due to the addition of microcrystalline cellulose, to solve the cough Biqing wet granulation tablet easy to absorb moisture phenomenon and the serious sticky punch phenomenon, and rapid
disintegration.

Microcrystalline cellulose can also be used as a sustained release agent for pharmaceutical products
.

The sustained release process is a porous structure
in which the active substance enters the carrier.

The active substance is contained by intermolecular hydrogen bonds, and after drying the active substance is fixed
.

When the active substance is released, due to the diffusion of water in the capillary system of the polymer carrier caused by swelling, the compound bond between the carrier and the fixed active substance is destroyed, and the active substance is slowly released
.

Microcrystalline cellulose powder can form a stable dispersion system in water, which can be combined with drugs to make creamy or suspended liquids, and can also be used as capsules
.

Microcrystalline cellulose is strongly stirred in water to form a gel, which can also be used to make pastes and suspension-type pharmaceutical preparations