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A major driver of the global obesity pandemic is overeating, the consumption of large quantities of tasty, high-calorie foodsOn August 26, 2022, the team of Zhu Yingjie from Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences revealed a different loop mechanism that promotes hedonic eating: the inhibitory loop projected from the lateral septal nucleus to the tubercle nucleus inhibits hedonic eating
Figure 1: Neuronal activation in the lateral septal nucleus during hedonic eating
Neurotensin (Nts), proenkephalin (Penk), and corticotropin-releasing factor are expressed in the LS region, among which Nts-positive neurons are mainly activated in hedonic eating behavior
Figure 2: Nts neurons in the LS region project to different downstream brain regions
Virus tracing experiments found that Nts neurons in the LS region project to the lateral and medial preoptic area (POA), tubercle nuclei (TU), anterior hypothalamic nucleus (AHN), and supramapillary nucleus (SUM)
Activation of the LS-Nts→TU loop can specifically inhibit palatable food and high-sugar food, but does not affect the intake of ordinary food
In situ hybridization experiments found that neurotensin receptors were mainly expressed in the SUM region, and less expressed in POA, TU and other regions
Figure 3: The LS-Nts→TU loop has a role in reducing high-fat diet-induced obesity
Mice on a high-fat diet for 6 weeks gained about 37% of their body weight, causing obesity, and a normal diet caused about a 14% increase in body weight in mice
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The pictures in the article are from the reference
