Domestic research teams use induced pluripotent stem cells to achieve T cell immune regeneration

T cell is a kind of immune cell that performs acquired immune function and plays an important role in anti-tumor, anti-virus infection and so on In recent years, the clinical immunotherapy (such as car-t, tcr-t) based on the cytotoxic principle of T cells has become a new way to treat malignant tumors After treatment, some cancer patients' condition has been relieved or even cured, and their survival and quality of life have been significantly improved However, the common dysfunction or depletion of T cells in cancer patients hinders the wide application of this therapy, so it is urgent to obtain new T cells from a wide spectrum and unlimited sources Around the in vitro regeneration of T cells, scientists have made unremitting efforts for a long time by simulating the microenvironment and key signaling pathway of T cell thymus development So far, there is no general and efficient method to induce pluripotent stem cells to achieve specific T immune system reconstruction in vivo On November 15, 2019, Wang Jinyong's research team from Guangzhou Institute of biomedicine and health, Chinese Academy of Sciences and Liu Bing's research team from the fifth medical center of the General Hospital of the people's Liberation Army and other domestic research teams published a report on cell research entitled "guiding t limphopoiesis from pluripotent step cells by defined transcription In the research paper of factors, it is reported for the first time that the co expression of transcription factors Runx1 and HOXA9 can effectively induce the pluripotent stem cells to differentiate into seed cells of T cells After transplantation, it can reconstruct the T immune system in immunodeficient mice, and the regeneration pathway can restore the immune surveillance function of T cells in immunodeficient mice This study established a method to induce the directed differentiation of pluripotent stem cells into T cell seeds by specific transcription factors (Runx1 and Hoxa9) This study uses pluripotent stem cells as materials to reconstruct the t-immune system, and to reconstruct the therapeutic significance of T-cell anti-tumor immunity It provides a new technical reference for the transformation research of T-cell-related immune defects (such as AIDS) and T-cell anti-tumor It is reported that the technology has applied for the priority of the International Patent Cooperation Treaty (PCT) and obtained the patent authorization protection in China