Microsphere preparation is a new dosage form, microspheres will be embedded in the drug or adsorbed on the surface of the polymer molecules, through subcutaneous injection or deep intramuscular injection into the human body, through the carrier surface rapid release, drug diffusion, polymer dissolution degradation and other ways, to achieve increased drug load, improve the encapsulation rate, targeted precision medication and other effects
.
Because microspheres can reduce the toxic side effects of drugs and improve the effectiveness and quality of drugs, their advantages are prominent, and market demand is continuing to grow
.
Domestic microsphere preparations are expected to usher in an outbreak period
Domestic microsphere preparations are expected to usher in an outbreak period
The domestic microsphere preparation industry started late, but after years of development, it is currently in a period of rapid development, and the market development prospects are broad
.
From the demand side, China is a big country with chronic diseases, with the intensification of aging, patients with chronic diseases such as malignant tumors, diabetes, cardiovascular and cerebrovascular diseases will continue to expand, which will drive the continuous growth
of demand for related drugs.
The microsphere technology has the advantages of prolonging the drug efficacy time, improving patient compliance, and optimizing the treatment effect, and has been widely used in the development and application
of long-acting sustained release injections.
With the continuous innovation of microsphere preparation technology and the accelerated layout of domestic pharmaceutical companies, the industry expects that the market size of microsphere drugs in chronic disease-related fields such as malignant tumors, heart diseases, cerebrovascular diseases will continue to grow, and is expected to usher in an outbreak period
.
Data show that from 2015 to 2019, the market size of China's microsphere preparation industry has increased from 2.
23 billion yuan to 4.
74 billion yuan, and the annual year-on-year growth rate during the period has exceeded 17%.
The industry predicts that by 2024, this market size will exceed the 10 billion yuan mark and grow to 11.
61 billion yuan
.
Pharmaceutical machinery enterprises actively expand the microsphere business layout
Pharmaceutical machinery enterprises actively expand the microsphere business layout
It is worth mentioning that the microsphere industry has high barriers, the difficulty of moving from the laboratory to industrial production is very high, and certain requirements
are also put forward for production equipment.
At present, many domestic pharmaceutical companies still rely on imported equipment, and the production equipment of microsphere preparations needs to be customized, and the overall cost is relatively high
.
In order to help the rapid development of the domestic microsphere preparation industry, in recent years, domestic pharmaceutical machinery enterprises represented by the head are accelerating the expansion of the microsphere business layout
.
For example, on September 17, Chutian Technology issued an announcement that the company accepted the institutional survey on September 16, 2022, in response to the company's microsphere business development, the company said that the laboratory's small test and pilot products have been out, some products are being tried by customers, and a small number of sales orders have been made
.
"We are about to start construction of a plant with a capacity of 500 million yuan, in addition to the agarose microspheres that have been developed for biomacromolecule pharmaceuticals, we will also develop fillers for food extraction, traditional Chinese medicine separation and other fields in the future, using 3-5 years to build a production capacity of 500,000 liters, and the future sales plan is more than
1 billion.
"
In addition, Dongfulong, as a comprehensive enterprise that can provide global pharmaceutical companies with pharmaceutical processes, core equipment and system engineering overall solutions, is also involved
in the microsphere business.
With the advancement of domestic microsphere preparation research and development, it has also promoted the growth of
demand for Dongfulong-related equipment.
It is reported that in the first half of 2021 alone, the company's injection stand-alone and system revenue reached 659 million yuan, an increase of 16.
22%
year-on-year.
In the industry's view, innovative microsphere preparations need the perseverance of "ten years of grinding a sword", and the equipment industry should also adhere to innovation and breakthroughs
.
Taking sterile equipment as an example, microsphere preparation generally cannot use terminal sterilization, so in the production process the demand to meet higher sterility requirements, for related preparation equipment requirements are also higher, domestic pharmaceutical machinery enterprises need to continue to innovate research and development, to create high-end equipment that meets the requirements, to help the industrial production
of microsphere preparation enterprises.
