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A recent study published in the journal FASEB found disorders of liver and skeletal muscle metabolism in young non-human primates fed a normal diet, whose mothers were obese
during pregnancy.
In the study, tissue biopsies captured 19 post-pubertal offspring whose mothers ate a Western diet during pregnancy but were obese, while 13 animals in the control group were born to non-obese mothers who ate a standard diet
.
All pups eat healthy foods
after weaning.
The researchers found that the offspring of obese mothers during pregnancy had 58 metabolites significantly altered in the liver and 46 metabolites in skeletal muscle, with 8 metabolites shared
in both tissues.
Several metabolic pathways
have been identified from these dysregulated metabolites.
These differences
in metabolites were not found in blood samples from animals.
"This study is exciting for two reasons: First, it shows that exposure to unhealthy environments in utero can have long-term health consequences, with different organs and tissues affected
in different ways.
Corresponding author Dr.
Michael Oliver, of Wake Forest University School of Medicine, said
.
"Second, our analysis shows that you can't just analyze a blood sample to understand what's going on
in the liver or muscles.
"
Maternal obesity alters offspring liver and skeletal muscle metabolism in early post-puberty despite maintaining a normal post-weaning dietary lifestyle
