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Prostate cancer (PCa is the most common cancer in men in industrialized countries, according to GLOBOCAN estimates, 1,276,106 new cases were registered worldwide in 2020, while 358,989 men died from this cancer worldwide
.
Over the past few decades, Many studies have focused on identifying the etiology of PCa, however, it remains largely unknown
Few original studies have focused on the impact of occupational factors on the occurrence of PCa before the 1990s
.
To date, we have included 5 cohorts [ 5-10 ] and 10 case-control studies [ 11-20 ], 2A literature review [ 21-23 ] and 2 meta-analyses [ 24 , 25 ] investigated the role of occupational factors on PCa risk, but the results were inconclusive
5-10 11-2021-23 24 25
EPICAP is a population-based French case-control study including 819 PCa cases and 879 matched controls
.
The characteristics of the EPICAP population are shown in Table 1
screening
All other characteristics of the study population were comparable between cases and controls, except for the first-degree family history of PCa (significantly different between cases and controls) ( p < 0.
001
) .
Regarding the lifetime career history of 1693 participants, there were 11,622 jobs over 6 months
p < 0.
statistics
The association between selected occupations (held and duration) and overall PCa is shown in Table 2
.
We observed a positive association (OR = 1.
See Table 2
For male carers who have worked in service jobs especially food and beverage processing
The association of selected occupations with PCa aggressiveness is shown in Table 3
.
We observed that for former professional, technical and related workers (OR = 1.
See Table 3
However, we did not observe a negative correlation with aggressive PCa in any occupational group
Original source:
Bijoux et al.
Occupation and prostate Cancer risk: results from the epidemiological study of prostate cancer (EPICAP).
Journal of Occupational Medicine and Toxicology (2022) 17:5
https://doi.
org/10.
1186/s12995-022-00346-2
