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Do human stem cells contain cancer-causing mutations?

 Last Update: 2022-04-25
 Source: Internet
 Author: User

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A team of scientists at the University of Exeter has shown that when stem cells are grown in their most primitive or primitive state, they do not contain any cancerous mutations

The research team's breakthrough will help ease the recent controversy over the genetic stability of human embryonic stem cells

The research was published Monday, December 14, 2020 in the leading peer-reviewed journal Cell Stem Cell

Human embryonic stem cells have great potential in regenerative medicine because they can be transformed into every cell in the human body, such as neurons, heart, pancreas and liver cells

They are an important potential source of cells that can be used to replace cells lost through injury or disease

Recent studies have shown that human pluripotent stem cells have been shown to increase the frequency of severe cancer-causing mutations

However, the new study, led by University of Exeter senior researcher Dr Ge Guo, showed no increase in the frequency of cancer-related genetic mutations found in these cells

The team analyzed RNA-sequencing data from human pluripotent stem cells and found that the actual incidence of cancer-causing mutations is close to zero

Cell Stem Cell (2020).

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