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| Diet is more beneficial to metabolic health and anti-aging |
A preclinical study in Australia showed that adjusting diet may be more effective than taking drugs in controlling diseases such as diabetes, stroke and heart disease
.
Studies have shown that nutrition (including total calories and macronutrient balance) has a greater impact on aging and metabolic health than the three commonly used diabetes and anti-aging drugs
This research builds on the team’s pioneering work in mice and humans, demonstrating that diet and specific combinations of protein, fat, and carbohydrate are effective for aging, obesity, heart disease, immune dysfunction, and metabolic diseases ( Such as type 2 diabetes, etc.
) risk protection
.
People have been trying to find drugs that improve metabolic health and aging without changing their diet
.
"Diet is a good medicine
Therefore, researchers set out to investigate whether drugs or diet are more effective in reshaping nutritional perception and other metabolic pathways, and whether the interaction between drugs and diet makes them more effective
.
The research team designed a complex mouse study, including 40 different methods, each with different protein, fat and carbohydrate, calorie and drug content
.
The research aims to detect the effects of three anti-aging drugs on the liver, which is a key organ that regulates metabolism
A key advantage of this research is the use of the nutritional geometry framework developed by Simpson and colleague David Raubenheimer
.
This framework allows researchers to consider how the mixing and interaction of different nutrients can affect health and disease, rather than focusing on any one nutrient alone-this is the limitation of other nutritional research
"We found that the diet has a much greater effect than drugs
.
Drugs have largely suppressed people's responses to diet, rather than reshaping them
The findings help to understand the mechanism between "what we eat" and "how do we grow old"
.
Studies have found that the balance of calorie intake and macronutrients (protein, fat, and carbohydrate) in the diet have a great impact on the liver
.
The intake of protein and total calories has a particularly large impact on metabolic pathways and the basic processes that control cell function
This creates a downstream effect, because the intake of protein and dietary energy affects the accuracy of cells in converting their genes into different proteins (helping cells to function normally and generating new cells), and these two basic processes are related to aging.
Related
.
In contrast, the role of drugs is mainly to inhibit the metabolic response of cells to diet, rather than to fundamentally reshape them
.
However, researchers have also discovered some more specific interactions between the biochemical effects of the drug and the dietary components
.
An anti-aging drug has a greater impact on cell changes caused by dietary fats and carbohydrates, while a cancer drug and another diabetes drug can block the effect of dietary protein on the energy-producing mitochondria
One of the authors of the paper, Professor David Le Couteur of the Charles Perkins Center, said that although the study is very complicated, it shows how important it is to study multiple different diets at the same time, rather than just comparing several different diets
.
"We all know what we eat can affect our health, but this study shows that food significantly affects many processes in human cells
Related paper information: https://doi.
org/10.
1016/j.
cmet.
2021.
10.
016
org/10.
1016/j.
cmet.
2021.
10.
016 https://doi.
org/10.
1016/j.
cmet.
2021.
10.
016
