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March 6, 2022 / Bio Valley BIOON / -- Diabetic cardiomyopathy (DCM, Diabetic cardiomyopathy) is a serious and underrecognized complication of diabetes, the first disease sign of the disease is diastolic dysfunction, The subsequent development of heart failure, the pathophysiological mechanism of DCM is currently unknown, but the changes in its microcirculation are very important
This gel-like layer, called glycocalyx, sits inside blood vessels and acts like a sieve to regulate how nutrients are transported from the blood to the heart and other tissues in the body
To understand whether repairing the glycocalyx would improve heart function, the researchers gave diabetic mice a substance that restores the structure of the glycocalyx, angiopoietin 1.
Scientists now have a better understanding of why people with diabetes develop heart failure, which often has no cure, and often do not have problems such as high blood pressure or coronary artery disease, which often lead to Heart failure, by contrast, tends to have problems with the small blood vessels that supply the heart muscle
Image source: https://link.
The researchers plan to identify key changes in the glycocalyx of diabetic patients, and further studies are needed to determine whether protecting the glycocalyx from damage can slow down the heart problems in these patients
Original source:
Qiu, Y.
