Diabetologia: A national case-control study has linked pregnancy failure to type 2 diabetes.

Type 2 diabetes causes more deaths than historically expected, and early predictions are critical to developing effective prevention strategies.
study suggests that pregnancy failure is a common event associated with atherosclerosis and isothermic heart failure and may be a predictor of type 2 diabetes.
the purpose of this study was to investigate whether pregnancy failure was related to the later development of type 2 diabetes.
across Denmark, researchers studied all women born between 1957 and 1997 and diagnosed with type 2 diabetes between 1977 and 2017.
in the Danish general population, a 1:10 ratio is made based on a woman's year of birth and level of education.
condition logistic regression model provides a different number of miscarriages of type 2 diabetes advantage ratio.
identified 24,774 women with type 2 diabetes and selected 247,740 non-diabetic control groups.
compared to pregnant women who did not have a loss of pregnancy, those who had type 2 diabetes in pregnant women who had failed 1, 2 and 3 times (pregnant women who had lost pregnancy) had type 2 diabetes, respectively, 1.18 (95% CI 1.13, 1.23), 1.38 (95% CI 1.27, 1.49) and 1.71 (95% CI 1.53, 1.92).
women who had never been pregnant had a 1.56 (95 percent confidence interval of 1.51, 1.61), compared to those who had been pregnant and had failed in any pregnancy.
similar results after correcting obesity and gestational diabetes.
found a significant and consistent link between pregnancy failure and subsequent type 2 diabetes, which increased with the number of pregnancy failures.
, failure to develop pregnancy and failure to relapse pregnancy are important risk factors for subsequent type 2 diabetes.
, future studies should explore whether this association is due to common background factors or prediabetes metabolic conditions.
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