Diabetes Care: Not only to control sugar!

The number of elderly people suffering from Alzheimer's disease (AD) and other forms of advanced dementia (LOD) is increasing exponentially, while at the same time, global life expectancy and population aging are increasing
.

Type 2 diabetes (T2DM) is another high-incidence chronic disease in later life, and is a recognized risk factor for dementia

Compared with subjects without diabetes, patients with diabetes have a 53-73% higher risk of LOD or AD

Most previous epidemiological studies have focused on defining the increased risk of dementia associated with the diagnosis or presence of diabetes
.

However, the biological mechanism of this relationship and the role of blood sugar control and diabetic complications in the development of dementia are not well understood

Most previous epidemiological studies have focused on defining the increased risk of dementia associated with the diagnosis or presence of diabetes

It is noteworthy that, variability of HbA1c is an important indicator of long-term control of diabetes, recently found that patients with diabetes micro- vascular positively correlated and macrovascular complications and mortality, has nothing to do with the level of HbA1c is worth noting, is the variability of HbA1c an important indicator of long-term control of diabetes, recently found that patients with diabetes micro- vascular shape and macrovascular complications and mortality positively correlated with HbA1c levels independent of blood vessels

In order to answer the above questions, experts from the Aging Epidemiology Laboratory of the School of Public Health, Imperial College London, UK, conducted a large-scale cohort study to study longitudinal HbA1c levels and diabetes complications and the onset of dementia in patients with type 2 diabetes.
Risk relationship
.

The results were published in the latest Diabetes Care magazine

The researchers analyzed the data of eligible diabetic patients aged ≥50 years in the UK clinical practice research data link from 1987 to 2018
.

The time-varying Cox regression method was used to estimate the adjusted hazard ratios (HRs) and 95% CIs of the risk of dementia

The relationship between time-varying HbA1c and HbA1c's 3-year CV and the risk of dementia

Among 457,902 diabetic patients, 28627 cases (6.
3%) of dementia were observed during the median follow-up period of 6 years
.

Compared with patients without such complications, patients with documented hypoglycemia events or microvascular complications have a 30% higher risk of dementia (HR=1.

Patients with documented hypoglycemic events or microvascular complications have a 30% higher risk of dementia compared with patients without such complications (HR=1.

Every 1% increase in HbA1c level is associated with an 8% increase in the risk of dementia (HR=1.

The relationship between diabetic complications and the risk of dementia in 457902 diabetic patients

In summary, the higher or unstable HbA1c level and the existence of diabetic complications in type 2 diabetic patients are related to the increased risk of dementia
.

Effective management of blood sugar may play an important role in maintaining the cognitive health of elderly diabetic patients
.

In summary, the higher or unstable HbA1c level and the existence of diabetic complications in type 2 diabetic patients are related to the increased risk of dementia
.
Effective management of blood sugar may play an important role in maintaining the cognitive health of elderly diabetic patients
.
In summary, the higher or unstable HbA1c level and the existence of diabetic complications in type 2 diabetic patients are related to the increased risk of dementia
.
Effective management of blood sugar may play an important role in maintaining the cognitive health of elderly diabetic patients
.
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references:

Glycemic Control, Diabetic Complications, and Risk of Dementia in Patients With Diabetes: Results From a Large UK Cohort Study.
Diabetes Care 2021 Jul; 44(7): 1556-1563.

Glycemic Control, Diabetic Complications, and Risk of Dementia in Patients With Diabetes: Results From a Large UK Cohort Study.
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