Diabetes Care: Diabetics with pancreatitis have a higher risk of pancreatic cancer than people with type 2 diabetes

Pancreatitis anddiabetesare recognized asrisk factors forpancreatic cancerSo far, however, the study has only looked at the risks associated with them individuallyA recent study published in Diabetes Care, an authoritative journal of diabetes, looked at the combined effects of pancreatitis and diabetes on pancreatic cancer risk, and the time-to-time relationship between themresearchers linked the National Cancer Registry to New Zealand discharge and mortality data between 1998 and 2015, identified four study groups (separate type 2 diabetes (T2D) group, separate pancreatitis group, T2D secondary pancreatitis group and pancreatitis follow-up diabetes (PPDM) group) incidence of primary pancreatic cancer, and T2D as a reference group for multivariate regression analysisThe researchers also conducted face-to-face comparisons between T2D, pancreatitis and PPDM groupsof 139,843 subjects (735,541 per year), 913 (0.7%) were diagnosed withdiagnosed with pancreatic cancerThe proportion of pancreatic cancer in patients with PPDM, follow-up to T2D pancreatitis, pancreatitis only and T2D-only patients was 3.1%, 2.3%, 2.0% and 0.6%, respectivelyPPDM (risk ratio of 6.94; 95% CI is 4.09-11.77) and T2D secondary pancreatitis (HR 5.35; 95% CI is 3.52-8.14) were significantly associated with pancreatic cancer compared to individual T2D patientsIn face-to-face comparisons, patients with PPDM had a higher risk of pancreatic cancer (2.35 HR; 95% CI 1.12-4.93) compared to T2D-following pancreatitis, pancreatitis significantly increases the risk of pancreatic cancer in diabeticsIn particular, PPDM has the highest risk of pancreatic cancer