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News from March 6, 2021 //--Although fruit flies have no ears, they can hear sounds with their antennae.
In a new study published in the journal Development, scientists from the Stem Cell Center of the University of Southern California describe how adult fruit flies regenerate sensory and auditory cells, and how the study of fruit flies can provide a new way to understand and develop treatments Treatments for hundreds of millions of hearing and balance disorders worldwide.
In a new study published in the journal Development, scientists from the Stem Cell Center of the University of Southern California describe how adult fruit flies regenerate sensory and auditory cells, and how the study of fruit flies can provide a new way to understand and develop treatments Treatments for hundreds of millions of hearing and balance disorders worldwide.
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Image source: pixabay.
com
com
"Drosophila provides a powerful method for studying the biological mechanisms of hearing and balance at the cellular, circuit, and behavioral level.
We can perform complex experiments on large groups of fruit flies quickly and economically, and we have mastered A detailed map of their genomes and neural circuits," said Ismael Fernández-Hernández, a postdoctoral researcher who led the study with co-author Evan Marsh and corresponding author Michael Bonaguidi.
We can perform complex experiments on large groups of fruit flies quickly and economically, and we have mastered A detailed map of their genomes and neural circuits," said Ismael Fernández-Hernández, a postdoctoral researcher who led the study with co-author Evan Marsh and corresponding author Michael Bonaguidi.
The sensory and auditory cells of Drosophila are located in the neurons of the antennae, which are called Johnston's organs (JO).
Despite the differences in morphology, the genetic programs and functions of these neurons in Drosophila and mammals are very similar.
Scientists can mark, track, and observe the newly-born JO neurons in live flies under a microscope.
Despite the differences in morphology, the genetic programs and functions of these neurons in Drosophila and mammals are very similar.
Scientists can mark, track, and observe the newly-born JO neurons in live flies under a microscope.
In healthy fruit flies, JO neurons regenerate naturally.
Scientists set out to discover a unique "origin of cell type".
However, they observed that JO neurons are proliferating and producing more self-cells-although this does not rule out the possibility that other types of cells can also produce JO neurons.
Scientists set out to discover a unique "origin of cell type".
However, they observed that JO neurons are proliferating and producing more self-cells-although this does not rule out the possibility that other types of cells can also produce JO neurons.
In fruit flies that were given the chemotherapy drug cisplatin, JO neurons compensated for the damage by proliferating more cells.
Cisplatin is known to kill sensory and auditory cells.
The researchers gave fruit flies another drug, which can enhance the production of neurons in the brain, and found that the proliferation of JO neurons also increased.
Cisplatin is known to kill sensory and auditory cells.
The researchers gave fruit flies another drug, which can enhance the production of neurons in the brain, and found that the proliferation of JO neurons also increased.
Scientists have also observed that JO neurons develop hair-like extensions, so-called cilia, and extend long nerve fibers-axons-into circuits related to hearing and balance in the brain.
These characteristics indicate that the new JO neurons are mature and may functionally transform existing circuits.
These characteristics indicate that the new JO neurons are mature and may functionally transform existing circuits.
Bonaguidi, assistant professor of stem cell biology and regenerative medicine at the Keck School of Medicine at the University of Southern California, said: “Drosophila has the potential to provide many insights on how to promote the regeneration of sensory and auditory cells.
Consider that one-third of people will suffer from hearing by the age of 80.
Or balance disorders, this is a very important research area.
"Our research results establish a new in vivo platform that will help speed up the search for drugs that promote its recovery.
"()
Consider that one-third of people will suffer from hearing by the age of 80.
Or balance disorders, this is a very important research area.
"Our research results establish a new in vivo platform that will help speed up the search for drugs that promote its recovery.
"()
News from March 6, 2021 //--Although fruit flies have no ears, they can hear sounds with their antennae.
In a new study published in the journal Development, scientists from the Stem Cell Center of the University of Southern California describe how adult fruit flies regenerate sensory and auditory cells, and how the study of fruit flies can provide a new way to understand and develop treatments Treatments for hundreds of millions of hearing and balance disorders worldwide.
In a new study published in the journal Development, scientists from the Stem Cell Center of the University of Southern California describe how adult fruit flies regenerate sensory and auditory cells, and how the study of fruit flies can provide a new way to understand and develop treatments Treatments for hundreds of millions of hearing and balance disorders worldwide.
jpeg" target="_blank">
jpeg" target="_blank">Image source: pixabay.
com
com
"Drosophila provides a powerful method for studying the biological mechanisms of hearing and balance at the cellular, circuit, and behavioral level.
We can perform complex experiments on large groups of fruit flies quickly and economically, and we have mastered A detailed map of their genomes and neural circuits," said Ismael Fernández-Hernández, a postdoctoral researcher who led the study with co-author Evan Marsh and corresponding author Michael Bonaguidi.
We can perform complex experiments on large groups of fruit flies quickly and economically, and we have mastered A detailed map of their genomes and neural circuits," said Ismael Fernández-Hernández, a postdoctoral researcher who led the study with co-author Evan Marsh and corresponding author Michael Bonaguidi.
The sensory and auditory cells of Drosophila are located in the neurons of the antennae, which are called Johnston's organs (JO).
Despite the differences in morphology, the genetic programs and functions of these neurons in Drosophila and mammals are very similar.
Scientists can mark, track, and observe the newly-born JO neurons in live flies under a microscope.
Despite the differences in morphology, the genetic programs and functions of these neurons in Drosophila and mammals are very similar.
Scientists can mark, track, and observe the newly-born JO neurons in live flies under a microscope.
In healthy fruit flies, JO neurons regenerate naturally.
Scientists set out to discover a unique "origin of cell type".
However, they observed that JO neurons are proliferating and producing more self-cells-although this does not rule out the possibility that other types of cells can also produce JO neurons.
Scientists set out to discover a unique "origin of cell type".
However, they observed that JO neurons are proliferating and producing more self-cells-although this does not rule out the possibility that other types of cells can also produce JO neurons.
In fruit flies that were given the chemotherapy drug cisplatin, JO neurons compensated for the damage by proliferating more cells.
Cisplatin is known to kill sensory and auditory cells.
The researchers gave fruit flies another drug, which can enhance the production of neurons in the brain, and found that the proliferation of JO neurons also increased.
Cisplatin is known to kill sensory and auditory cells.
The researchers gave fruit flies another drug, which can enhance the production of neurons in the brain, and found that the proliferation of JO neurons also increased.
Scientists have also observed that JO neurons develop hair-like extensions, so-called cilia, and extend long nerve fibers-axons-into circuits related to hearing and balance in the brain.
These characteristics indicate that the new JO neurons are mature and may functionally transform existing circuits.
These characteristics indicate that the new JO neurons are mature and may functionally transform existing circuits.
Bonaguidi, assistant professor of stem cell biology and regenerative medicine at the Keck School of Medicine at the University of Southern California, said: “Drosophila has the potential to provide many insights on how to promote the regeneration of sensory and auditory cells.
Consider that one-third of people will suffer from hearing by the age of 80.
Or balance disorders, this is a very important research area.
"Our research results establish a new in vivo platform that will help speed up the search for drugs that promote its recovery.
"()
Consider that one-third of people will suffer from hearing by the age of 80.
Or balance disorders, this is a very important research area.
"Our research results establish a new in vivo platform that will help speed up the search for drugs that promote its recovery.
"()
Original source: Ismael Fernández-Hernández et al.
biologists.
org/content/early/2021/02/17/dev.
187534">Mechanosensory neuron regeneration in adult Drosophila, Development (2021).
DOI: 10.
1242/dev.
187534
biologists. biologists.
org/content/early/2021/02/17/dev.
187534">Mechanosensory neuron regeneration in adult Drosophila, Development (2021).
DOI: 10.
1242/dev.
187534
org/content/early/2021/02/17/dev.
187534">Mechanosensory neuron regeneration in adult Drosophila,
