Developing Chinese medicine: more "non-it-it"

"So far, China has produced only two internationally recognizedChinese medicinenew drugs" has become the 14th NationalChinese medicineand natural medicine symposium held recently, by experts mentioned the most wordsYe Zuguang, director and lead researcher of the Center for Drug Safety Evaluation at the Chinese Academy of Traditional Chinese Medicine, said that china has developed dozens or even hundreds of new Chinese medicines each year, but that the only chinese medicine skits that have reached the level of "out of this medicine" in the treatment of a disease, only artemisinin and arsenic trioxideYe Zuguang believes that in the past 30 years, China's research and development of new Chinese medicine not only a large number of new drugs, but also in clinical medicine in the forefront of the level of new drugs square, there is no shortage of such as lianhua qing plague capsules, compound dansin drop pills, thrombosis injections and other "advantages and characteristics" of chinese medicine, but China's new Chinese medicine also lack of "hands" and cause more "sensational effect" at home and abroadThe so-called "get hands" and "sensational", is that this drug in the clinical disease first-line drug treatment is "non-other" rather than optionalHe gave an exampleIn 2011, China won the famous award "Lasker Award" in the field of biomedical science, which was not the initiative to apply for research and development personnel of antimalarial drugs such as artemisinin in China, but was recommended by a third party, which caused quite a stir in China's pharmaceutical industry at that timeMillions of children's lives have been saved as a result of the advent of artemisinin, according to the CommitteeChina is a large research country of natural products, 40% of the international natural product chemistry papers from China, each year more than 4000 new natural products, found a large number of active ingredientshowever, "active does not mean new drugs"Zhang Weidong, a professor at the Second Military Medical University, believes that the target discovery and optimization of new Chinese medicine is not enough, and that the in-depth research is not sufficient, which is the main reason why the active ingredient is not enough to become a clinical first-line drug" basic research is one of the important sources of innovative drug research and development"Ye Zuguang believes that the emergence of any new drug is closely related to the progress of basic research and its new knowledge," the company, which is dominated by the sea-returning personnel, first discovered the new estrogen er36 receptor in the basic research, and then found that the receptor and a number of tumors occurred and developed with correlation, on this basis, screening and research ingressing a class of new Chinese medicine to treat liver cancer, the drug is expected to complete clinical research and be approved by the drug regulatory department to go on the market"
" will be the old Chinese medicine clinical experience and modern medicine combined, sublimation into a perfect innovation of new drugs, this is our new drug research and development advantages, but also 'get hands' of new drugs an important way to produce "Ye Zuguang with the well-known Chinese medicine ophthalmologist Professor Tang Byu zhi and pharmaceutical experts combined to develop a new Chinese medicine eye drops as an example, to illustrate the importance of the combination of the above two, Tang Byu based on his own years of clinical experience to develop a treatment of eye disease sleathing, but the eye drops have a short-term effect of defects Chinese medicine preparation experts will be eye drops into gel dyslenosicing drugs, extending the action time of the drug, thereby improving the effectiveness of the old Chinese medicine eye drops faced with the embarrassing situation that only two new drugs can get their hands on, Zhang Weidong pointed out, "Most modern Chinese medicine has no clear molecular targets, the mechanism of action is not clear, mostly in some disease animal models partially verified the therapeutic effect, from the level of research and development is difficult to be accepted by the international pharmaceutical mainstream academia and industry." "
Ye Zuguang called for, while strengthening basic research, we should attach importance to the treatment experience, ideas and their experience in chinese medicine theory, so that it can be combined with modern pharmacy and pharmaceutical theory, to develop more rich Chinese medicine characteristics and more effective New Chinese medicine, so as to benefit the world, benefit all mankind he also suggested that the clinical hospitals of Chinese medicine should be strengthened to carry out "clinical practice with scientific research", to find, optimize and evaluate in the treatment, and ultimately to develop and produce new Chinese medicine (Responsible Editor: yf001)