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| Determination of early markers of diseases such as Alzheimer's disease |
Science and Technology Daily, Beijing, October 31.
(Intern reporter Zhang Jiaxin) According to a paper recently published in the journal Science Translational Medicine, researchers at the Medical University of South Carolina and Harvard Medical University Beth Israel Deaconess Medical Center found that cis P- Tau is a toxic, non-degradable brain protein and an early marker of vascular dementia (VAD) and Alzheimer's disease (AD)
.
This new research opens the door to new potential immunotherapies.
Research has determined the molecular mechanism that causes the accumulation of this toxic protein
.
At the same time, it is shown that monoclonal antibodies (mAb) against cis P-tau can prevent disease pathology and memory loss in preclinical models of AD and VAD
In the preclinical model of VAD, pups showed signs of brain inflammation and memory loss within one month
.
However, treatment of these mice with cis P-tau mAb can prevent neurodegeneration and cognitive decline within 6 months
It is often difficult to translate information obtained from preclinical models into the human body, but this study provides reasons for optimism
.
Researchers have found that treatment with cis P-tau mAb can reverse 85% to 90% of pathological changes, which demonstrates the power of this potential therapy
Aging is a normal physical aging phenomenon.
We will experience the process of bone and muscle weakness, blood vessel stiffness, and partial memory loss
.
However, about 50 million people around the world suffer from more and more memory decline, and eventually suffer from dementia
Dementia is an umbrella term that covers Alzheimer's disease, which accounts for 60% to 80% of cases.
The second most common cause is vascular dementia
.
Currently, there is no effective treatment for Alzheimer's disease
The researchers said that these two diseases may not be the only diseases affected by high levels of cis P-tau
.
This toxic protein may also cause other brain diseases that contain vascular components, but further research is needed to establish its connection
