Detection of early serum miR-1297 predictable prognosis of function in aSAH patients

Bin Sheng of the First Hospital of Neurosurgery, affiliated with Minnan Medical College in Anhui Province, tested serum miR-1297 as a biomarker of aneurystic cobweb subcavity hemorrhage (aSAH) to assess the relationship between expression levels and the prognosis of post-aSAH function, published in the November 2018 issue of Bio Repsci- Excerpted from the article chapterRef: Sheng B, et alBiosci Rep.2018 Nov 20; 38 (6)pii: BSR20180646doi: 10.1042/BSR20180646Print 2018 Dec 21.)MicroRNAs (miRNAs) is a highly conservative class of non-coding RNA molecules consisting of approximately 22 nucleotides that play a key role in regulating mRNA translationStudies have shown that the level of miRNA in circulating blood is associated with clinical prognosis in patients with ischemic stroke, suggesting that serum miRNA can be used as a biomarker for tissue damageBin Sheng of the First Hospital of Neurosurgery, affiliated with Minnan Medical College in Anhui Province, tested serum miR-1297 as a biomarker of aneurystic cobweb subcavity hemorrhage (aSAH) to assess the relationship between expression levels and the prognosis of post-aSAH function, published in the November 2018 issue of Bio Repscithe study collected aSAH patients admitted between May 2015 and January 2016Patients all develop aSAH prior to admission, admitted to the intensive care unit within 24 hours of the first symptoms, CT shows SAH, DSA detects aneurysm; Exclude patients who are admitted to hospital 24 hours after aSAH undiagnosed, non-aneurysm-based SAH, SAH onset, intravascular intervention therapy or open cranial clamped aneurysm, and patients with no intervention and poor prognosis after admissionASAH severity was assessed with WFNS, Hunt-Hess, and Improved Fisher scoresThe functional prognosis after 1 year in patients with aSAH was detected with an improved Rankin scale (mRS) scoreSerum was collected at 4 different points in time, i.e24 hours, 72 hours, 168 hours and 14 days, for serum miR-1297 in aSAH patients and control group healthy people a total of 128 patients and 40 healthy patients in the control group were included in the The aSAH group consisted of 54 males and 74 females, aged 36-83, with a median age of 59 years The health control group included 20 males and 20 women, aged 26-64, with a median age of 45 years The results of the single-factor analysis showed that the higher level of miR-1297 at the above four points in time, the WFNS score, the Hunt-Hess score and the fisher score were all significantly correlated with the adverse prognosis after one year (Table 1) Table 1 Multivariar analysis of poor functional prognosis after 1 year in patients with aSAH The serum miR-1297 concentration in patients in the aSAH group was significantly higher than in healthy people in the control group (Figure 1) Serum miR-1297 concentrations were significantly correlated with aSAH severity The miR-1297 levels were 0.80, 0.94, 0.77 and 0.59 under the characteristic curve of the subjects at 4 point in time between the aSAH patients and the control group healthy Multifactory logistic regression analysis showed that 24-hour and 72-hour miR-1297 levels were able to predict the functional prognosis after 1 year Figure 1 The aSAH group compared the level seromiR-1297 in healthy patients in the control group results show that serum miR-1297 levels are independent predictors of poor 1-year prognosis in aSAH patients after surgery, and can be used to determine the prognosis of aSAH patients.