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Recent studies have shown that cancer is associated with cardiovascular disease.
some chemotherapy drugs have cardiac toxicity, studies have also shown that heart failure and stress are associated with poor cancer prognostication.
, however, it is not clear whether chamber reconstruction will affect cancer development without heart failure.
to study the effects of early cerial reconstruction on tumor growth and metastasis cloning, researchers used lateral aortic narrowing (TAC) to induce cerial hypertrophosis and then implant cancer cells.
(TAC-operated mice developed larger primary tumors, had higher proliferation rates, and showed more metastasis lesions than the control group.)
in mice with TATC surgery can enhance the proliferation of cancer cells in vitro, indicating the presence of tumor-promoting factors.
RNA sequencing, the researchers found that in the hearts of TAC-operated mice, the mRNA levels of osteofilm increased.
also detected elevated levels of osteofilm in the serum of mice after TATC surgery.
osteoficin in the depleted serum can stop cancer cell proliferation;
is the first to reveal that early acosm reconstruction can promote tumor growth and metastasis, which in turn promotes cancer progression.
: This study highlights the importance of early diagnosis and treatment of adlysitous reconstruction, as improvements in adyric reconstruction may slow cancer progression and improve cancer prognosis.
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