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The products produced by the existing domestic amoxicillin process have small average particle size, high coefficient of variation, high impurity residues and poor product stability
.
The advantages of the integrated crystallization, filtration, washing and drying machine used in the purification and purification process of amoxicillin are: less colored impurities, high yield of amoxicillin, good product quality, and at the same time, the recovery of qualified styrene ethyl suan, which is easy to be applied in production
.
The following editor briefly introduces the process steps of the crystallization, filtration, washing and drying integrated machine applied to the purification and purification of amoxicillin, as follows: (1) Extraction step The reaction solution is cooled, and then dichloromethane is added
.
Under stirring condition, adding mass concentration is 20～30% hydrochloric acid, separates dichloromethane phase; Carry out secondary extraction and tertiary extraction, finally obtain the extraction water phase containing 6-APA, and merge dichloromethane phase; ( 2) Amoxicillin reaction preparation step Add ammonia water to the extraction water phase containing 6-APA, at room temperature, remove the residual dichloromethane in the extraction water phase under reduced pressure; the obtained solvent removal 6-APA solution is subjected to pressure reduction.
Filtration and concentration; synthesis reaction and separation to obtain amoxicillin crude product; step (3) acidifying and dissolving in the main shaft of the crystallization, filtration, washing and drying all-in-one machine, and adding 20-30% hydrochloric acid to the amoxicillin crude product to make amoxicillin Moxicillin is completely dissolved, and then filtered; (4) Under cooling conditions, add ammonia water with a mass concentration of 6 to 10% to the amoxicillin solution, control the pH of the feed liquid to be 4.
8 to 5.
2, and keep under cooling conditions.
(5) Suction filtration, washing and drying The amoxicillin crystal solution was suction filtered by the crystallization filtration washing and drying multi-function machine, washed with purified water and acetone respectively, and then the amoxicillin wet powder was washed with Vacuum low-temperature drying, the temperature is 40-60 DEG C, the vacuum degree is ≥0.
085MPa, and after drying, the amoxicillin dry powder is obtained
.
.
The advantages of the integrated crystallization, filtration, washing and drying machine used in the purification and purification process of amoxicillin are: less colored impurities, high yield of amoxicillin, good product quality, and at the same time, the recovery of qualified styrene ethyl suan, which is easy to be applied in production
.
The following editor briefly introduces the process steps of the crystallization, filtration, washing and drying integrated machine applied to the purification and purification of amoxicillin, as follows: (1) Extraction step The reaction solution is cooled, and then dichloromethane is added
.
Under stirring condition, adding mass concentration is 20～30% hydrochloric acid, separates dichloromethane phase; Carry out secondary extraction and tertiary extraction, finally obtain the extraction water phase containing 6-APA, and merge dichloromethane phase; ( 2) Amoxicillin reaction preparation step Add ammonia water to the extraction water phase containing 6-APA, at room temperature, remove the residual dichloromethane in the extraction water phase under reduced pressure; the obtained solvent removal 6-APA solution is subjected to pressure reduction.
Filtration and concentration; synthesis reaction and separation to obtain amoxicillin crude product; step (3) acidifying and dissolving in the main shaft of the crystallization, filtration, washing and drying all-in-one machine, and adding 20-30% hydrochloric acid to the amoxicillin crude product to make amoxicillin Moxicillin is completely dissolved, and then filtered; (4) Under cooling conditions, add ammonia water with a mass concentration of 6 to 10% to the amoxicillin solution, control the pH of the feed liquid to be 4.
8 to 5.
2, and keep under cooling conditions.
(5) Suction filtration, washing and drying The amoxicillin crystal solution was suction filtered by the crystallization filtration washing and drying multi-function machine, washed with purified water and acetone respectively, and then the amoxicillin wet powder was washed with Vacuum low-temperature drying, the temperature is 40-60 DEG C, the vacuum degree is ≥0.
085MPa, and after drying, the amoxicillin dry powder is obtained
.
