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Deleting a protein may reduce cardiovascular disease

 Last Update: 2022-04-23
 Source: Internet
 Author: User

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Macrophages travel through our arteries and devour fat the way Pac-Man devours ghosts

Macrophages are large white blood cells that roam our bodies like a swarm of scavengers cleaning up dangerous debris

Changing the way macrophages express a certain protein can prevent this undesirable behavior, reports a team of researchers at the University of Connecticut Health

"They form a vicious cycle that promotes the development of atherosclerosis

Graduate students Pengyu Yue and Pengyu Zong, lead authors of the paper, demonstrated a way to stop this cycle, at least in mice

Now, Yue and Pengyu Zong, along with the rest of the team, are investigating whether increased TRPM2 expression in blood monocytes (precursors of macrophages) is associated with the severity of cardiovascular disease in humans

The research was funded by the American Heart Association and the National Heart, Lung, and Blood Institute of the National Institutes of Health

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