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Thanks to advances in early diagnosis and cancer treatment, more and more cancer patients are surviving
Thanks to advances in early diagnosis and cancer treatment, more and more cancer patients are surviving
The triglyceride-glucose (TyG) index has been introduced as a surrogate marker of insulin resistance and can be easily calculated using fasting glucose and triglyceride levels without sampling serum insulin
The triglyceride-glucose (TyG) index has been introduced as a surrogate marker of insulin resistance and can be easily calculated using fasting glucose and triglyceride levels without sampling serum insulin
Baseline characteristics of the study population
Baseline characteristics of the study populationA total of 155,167 cancer survivors (mean age 59.
A total of 155,167 cancer survivors (mean age 59.
Association of TyG index with cardiovascular events
Association of TyG index with cardiovascular eventsFor primary cardiovascular events, a gradual increase in risk was observed at the TyG index level
For primary cardiovascular events, a gradual increase in risk was observed at the TyG index level
When analyzing the association of TyG index with CVD subtypes, the graded positive association between TyG index and clinical outcomes was particularly evident for atherosclerotic cardiovascular disease (ASCVD), such as IHD (including AMI) and ischemic stroke , rather than hemorrhagic stroke or heart failure
When analyzing the association of TyG index with CVD subtypes, the graded positive association between TyG index and clinical outcomes was particularly evident for atherosclerotic cardiovascular disease (ASCVD) such as IHD (including AMI) and ischemic stroke , not hemorrhagic stroke or heart failure .
Restricted cubic splines for primary cardiovascular events showed a similar positive correlation of grades observed in categorical analyses (Fig.
When a linear association was assumed, each 1-unit increase in the TyG index was associated with a 16% increase in primary cardiovascular events (HR 1.
When a linear association was assumed, each 1-unit increase in the TyG index was associated with a 16% increase in primary cardiovascular events (HR 1.
Exploratory Analysis: Association of Individual Fasting Glucose and Triglyceride Levels with Primary Cardiovascular Events
Exploratory Analysis: Association of Individual Fasting Glucose and Triglyceride Levels with Primary Cardiovascular EventsWith regard to fasting blood glucose, the baseline covariate-adjusted risk of fasting blood glucose levels ≥140 mg/dL was significantly increased compared with the reference group with fasting blood glucose levels <100 mg/dL
With regard to fasting blood glucose, the baseline covariate-adjusted risk of fasting blood glucose levels ≥140 mg/dL was significantly increased compared with the reference group with fasting blood glucose levels <100 mg/dL
The current study showed that the TyG index was positively associated with cardiovascular events in a dose-dependent manner in a large nationwide cohort involving more than 150,000 cancer survivors
The current study showed that the TyG index was positively associated with cardiovascular events in a dose-dependent manner in a large nationwide cohort involving more than 150,000 cancer survivors
.
Similar results were observed in subgroups of different ages and genders
.
Notably, the positive associations were significant for grades of ASCVD subtypes (eg, IHD, AMI, and ischemic stroke) , but not hemorrhagic stroke or heart failure
.
In addition, the slope of the association between AMI and ischemic stroke was higher
.
This study is also the first to demonstrate the risk of developing CVD based on the baseline TyG index of cancer survivors
.
The TyG index may serve as a simple surrogate marker for risk stratification of future CVD events in cancer survivors
.
Notably, the grading of ASCVD subtypes (eg, IHD, AMI, and ischemic stroke)
Original source:
Original source:Jung MH, Yi SW, An SJ, et al.
Associations between the triglyceride-glucose index and cardiovascular disease in over 150,000 cancer survivors: a population-based cohort study.
Cardiovasc Diabetol .
2022;21(1):52.
Published 2022 Apr 16.
doi: 10.
1186/s12933-022-01490-z
Associations between the triglyceride-glucose index and cardiovascular disease in over 150,000 cancer survivors: a population-based cohort study.
Cardiovasc Diabetol .
2022;21(1):52.
Published 2022 Apr 16.
doi: 10.
1186/s12933-022-01490-z Cardiovasc Diabetol
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