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There is fibrin in the blood, and fibrin is activated and hydrolyzed to produce specific degradation products called "fibrin degradation products
.
" D-dimer is the simplest fibrin degradation product, and elevated D-dimer levels indicate hypercoagulability and secondary hyperfibrinolysis
.
Therefore, the mass concentration of D-dimer is of great significance
for the diagnosis, efficacy assessment and prognosis of thrombotic diseases.
The normal value range of different reagents is different, generally <0.
3mg/L or <0.
5mg/L
.
Clinical significance
D-dimer is derived from plasmin-soluble cross-linked fibrin clots that primarily reflect fibrinolytic function
.
The clinical detection of D-dimer is mainly used in the diagnosis
of venous thromboembolism (VTE), deep vein thrombosis (DVT) and pulmonary embolism (PE).
Increased: seen in secondary hyperfibrinolytic function, such as hypercoagulable state, disseminated intravascular coagulation, kidney disease, organ transplant rejection, thrombolytic therapy, etc
.
Myocardial infarction, cerebral infarction, pulmonary embolism, venous thrombosis, surgery, tumors, disseminated intravascular coagulation, infection, and tissue necrosis can also lead to elevated
D-dimers.
