Curcumin inhibits NF - κ B signaling pathway in breast cancer metastasis
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Last Update: 2012-07-02
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Source: Internet
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Author: User
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Curcumin is a kind of chemical component extracted from the rhizome of some plants in Zingiberaceae and Araceae, among which curcumin is about 3% - 6%, which is a rare pigment with diketone in the plant kingdom Recently, curcumin has been reported to have anti-cancer effects, but the molecular mechanism of this anti-cancer effect is not completely clear In a recent study published in the journal Molecular Biology reports, the researchers evaluated the effect of curcumin on human breast epithelial cells MCF-7 The activity of tumor cells was detected by MTT after curcumin treatment The invasiveness of cells was detected by Transwell cell The activity of NF - κ B binding DNA was detected by ELISA Kit across am NF - κ B Western blot was used to detect the effect of curcumin on the expression of uPA The results showed that curcumin inhibited the proliferation of MCF-7 cells in a dose-dependent manner At the same time, the adhesion and invasion of MCF-7 cells treated with curcumin were significantly inhibited Curcumin also significantly decreased the expression of uPA and the DNA binding activity of NF - κ B The data show that curcumin can inhibit the adhesion and invasion of MCF-7 cells by inhibiting the activation of NF - κ B and down regulating the expression of uPA The researchers hope that the therapeutic potential of curcumin for breast cancer deserves further study.
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