CTM: Large-scale population study that uses line chart strains to predict distant metastasis and overall survival of colorectal cancer patients

There were 148,000 new colorectal cancer (CRC) patients in the United States in 2019 alone, of which 146 died every day, the third highest rate of death of any malignant tumorOver the past 30 years, the incidence and overall survival rate (OS) of CRC has been increasing worldwideThe 5-year CRC OS is about 65.2%The main causes of CRC survival are distant metastasis, including liver, lung, brain and bone metastasisApril 29, 2020, Clinical and Translational Medicine magazine published online the latest results of Professor Peng Junjie's team at Fudan University, "Nomograms for pronal dataand sites and overall search of the color cancer s: A large-strength-population-real-world research"study was designed to produce a line that predicted the remote ness and overall survival of CRC patientsThe authors conducted a large-scale retrospective study of CRC cases based on existing public databasesA column chart was then produced that could predict the probability of distant transfer and overall survival at a specific site in CRC patientsThe functional effect of the line chart is evaluated by c-index, corrected curve, area under curve (AUC), decision curve (DCA) and so oncollected a total of 142,343 cases in this studyThe results of single and multivariate analysis show that some clinical pathological features are related to distant transfer and survival of specific sites, and a line chart is producedThe results show that the resulting column chart can predict a particular distant transfer point very accuratelyC-index predicted liver, lung, bone and brain metastasis was 0.82 (95% trust interval (CI), 0.81-0.83), 0.80 (95% CI, 0.78-0.81), 0.83 (95% CI, 0.79-0.86) and 0.73 (95%, CI.72-0.84)Then a prognostic column chart of 1 year, 3 year, and 5 yearOS can be predicted in PATIENTs with CRC, which combines CRC clinical pathology characteristics and specific distant transfer sites, resulting in AUCs of 0.764 (95% CI, 0741-0.783), 0.762 (95% CI, 0.745-0.781) and 0.745 (95% CI, 0.730-0.761) DCA shows that the clinical application value of prognostic line charts is better than that of the current TNM staging system conclusion sitted for clinicians based on clinical pathological characteristics to predict specific distant transfer sites and OS in CRC patients This helps to personalize CRC patients after surgery in summary, , the authors have created a new column chart for CRC patients that predicts specific distant transfer sites and OS This simple and clear line chart not only has good clinical application value, but also has sufficient differentiation and calibration functions This helps clinicians evaluate the prognosis of each CRC patient and develop individualized treatment options Peng Junjie, Peng Junjie, male, deputy director of large-scale gastrointestinal surgery at Fudan University's affiliated oncology hospital He graduated from Fudan University's Department of Clinical Medicine and, in 2009, ph.D in Oncology, Fudan University's Affiliated Oncology Hospital He has been engaged in clinical postdoctoral research at the UcSF Oncology Center Since 2006, he has been working in the great gastrointestinal surgery of Fudan University's affiliated oncology hospital and has served as a resident and attending physician He is currently a member of the hepatic metastatic section of the Colorectal Cancer Professional Committee of the Chinese Society of Cancer, a member of the Professional Committee of Colorectal Cancer of the Surgical Branch of the Chinese Physicians Association, a youth member of the Multidisciplinary Collaboration Committee of the Surgical Branch of the Chinese Physicians Association, and a member of the Colorectal Cancer Group of the Chinese Family Genetic Collaboration Group Mainly specializes in colorectal cancer root surgery, minimally invasive surgery and multidisciplinary comprehensive treatment, in hereditary colorectal cancer, colorectal cancer liver metastasis and advanced colorectal cancer in the chemotherapy sensitivity of in-depth study Member of the Hepatology Committee of the Colorectal Cancer Professional Committee of the Chinese Association of Cancer Youth
Committee of the Professional Committee of colorectal cancer of the Surgical Branch of the Chinese Physicians Association references Siegel RL, Miller KD, Jemal A Cancer Statistics, 2020 CA Cancer J Clin 2020;70(1):7-30 2 Zhou Z, Mo S, Dai W, et al Prognostic nomostudygrams for pro-pre-survival and general survival of phase i-III colon cancer s: a large population-population Cell Cancer Int 2019; 19:355 3 O'Connell JB, Maggard MA, Ko CY Colon cancer cancer rates with the new American Joint Committee on Cancer Sixth Edition J Natl Cancer Inst 2004;96 (19):1420-1425 4 Zhou Z, Mo S, Dai W, et al Development and validation of an autophagy signature score for the prediction of post-operative survival in colorectal cancer Front Oncol 2019;9:878 5 Gryfe R, Kim H, Hsieh ET, et al Tumor microssininstability and clinical outcome in young patients with colorectal cancer N Engl J Med 2000;342 (2):69 77 6 Mo S, Cai X, Zhou Z, et al Nomograms predict foring the pre distant metastatic sites and overall survival of the color cancer cancer patients: A large population-real real-world study Clin Transl Med 2020;10:169–181 Author: Cheng Xin Source: CTMWorld highlights: zhouzheng97 on 2020-5-21 Comment: good (from: MedSci Medical ) day 020-5-21 Comment: good learning opportunities
(from: MedSci Medical ) njwbhuang on 2020-5-21 comment: will also have an advantage in the statistical methods of the (from: MedSci Medical App ) lovetcm at 2020-5-21 commented: "
line chart is just a method
(from: MedSci Medical App )