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Researchers at Tel Aviv University have for the first time cracked a mechanism that enables skin cancer to metastasize to the brain and have successfully delayed the spread of the disease by 60 to 80 percent
Professor Satchi-Fainaro explains: "In the advanced stages, 90% of patients with melanoma (skin cancer) develop brain metastases
Researchers from Tel Aviv University have found that in brain-metastatic melanoma patients, cancer cells "recruit" a type of cell called astrocytes, which are found in the spinal cord and brain and are responsible for homeostasis, or maintaining a stable state
Professor Satchi-Fainaro said: "Astrocytes are the first cells to correct a condition in the event of a stroke or trauma, with cancer cells interacting with astrocytes to exchange molecules and corrode them
To test their hypothesis, Professor Satchi-Fainaro and her team sought to inhibit the expression
Professor Satchi-Fainaro said: "These treatments have been successful in delaying the entry of cancer cells into the brain and subsequent spread
The study was conducted in collaboration with other scientists and doctors from Tel Aviv University, including Professor Adi Barzel, Dr.
The study was funded
Sabina Pozzi, Anna Scomparin, Dikla Ben-Shushan, Eilam Yeini, Paula Ofek, Alessio D.